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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

Tramadol in combination with acetaminophen vs placebo

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen probably leads to higher number of participants experiencing any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs NSAIDs

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen showed no clear difference in number of participants experiencing any adverse event compared with NSAIDs (low certainty).

1 finding from 1 review