Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Metabolic and Endocrine Disorders

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 1 · 14.3%Moderate 1 · 14.3%High 0 · 0%

Acarbose vs placebo

All‐cause mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether acarbose changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in… 2018 · Cochrane Headline outcomes only
RR 0.98 [0.82, 1.18]
3 studies · 8069 participants
Very low

Acarbose vs placebo

Development of type 2 diabetes · people at increased risk for developing type 2 diabetes

Acarbose probably leads to lower incidence of T2DM compared with placebo (moderate certainty).

1 finding from 1 review

Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in… 2018 · Cochrane Headline outcomes only
RR 0.82 [0.75, 0.89]
3 studies · 8008 participants
Moderate

Acarbose vs placebo

Serious adverse events · people at increased risk for developing type 2 diabetes

Acarbose showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in… 2018 · Cochrane Headline outcomes only
RR 1.12 [0.97, 1.29]
2 studies · 6625 participants
Low

Acarbose vs placebo

Cardiovascular mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether acarbose changes cardiovascular mortality compared with placebo (very low certainty).

1 finding from 1 review

Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in… 2018 · Cochrane Headline outcomes only
RR 0.88 [0.71, 1.1]
3 studies · 8069 participants
Very low

Acarbose vs placebo

(1) Non‐fatal myocardial infarction (2) Non‐fatal stroke (3) Congestive heart failure · people at increased risk for developing type 2 diabetes

It is very uncertain whether acarbose changes (a)Non‐fatal myocardial infarction (b)Non‐fatal stroke (c)Congestive… compared with placebo (very low certainty).

1 finding from 1 review

Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in… 2018 · Cochrane Headline outcomes only
RR 0.1 [0.02, 0.53]
2 studies · 1486 participants
Very low

Acarbose vs placebo

Health‐related quality of life · people at increased risk for developing type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acarbose vs placebo

Socioeconomic effects · people at increased risk for developing type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found