Findings

What do systematic reviews say?

46 questions · 46 findings · 4 reviews

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No studies found 3 · 6.5%GRADE not reported 1 · 2.2%Very low 20 · 43.5%Low 16 · 34.8%Moderate 6 · 13%High 0 · 0%

Azathioprine or 6‐mercaptopurine vs placebo

Withdrawals due to adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 3.12 [1.59, 6.09]
7 studies · 661 participants
Very low

Azathioprine or 6‐mercaptopurine vs placebo

Serious adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 2.45 [1.22, 4.9]
4 studies · 556 participants
Very low

Azathioprine or 6‐mercaptopurine vs mesalazine or sulfasalazine

Maintenance of remission · maintenance of remission in Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in maintenance of remission compared with mesalazine or sulfasalazine (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1.09 [0.88, 1.34]
2 studies · 166 participants
Low

Azathioprine or 6‐mercaptopurine vs mesalazine or sulfasalazine

Adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes adverse events compared with mesalazine or sulfasalazine (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 8.77 [0.54, 142.51]
1 study · 45 participants
Very low

Azathioprine or 6‐mercaptopurine vs mesalazine or sulfasalazine

Withdrawals due to adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with mesalazine or sulfasalazine (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1.86 [0.87, 3.97]
2 studies · 290 participants
Very low

Azathioprine or 6‐mercaptopurine vs mesalazine or sulfasalazine

Serious adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes serious adverse events compared with mesalazine or sulfasalazine (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 9.37 [1.84, 47.72]
2 studies · 235 participants
Very low