Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 1 · 16.7%Moderate 1 · 16.7%High 0 · 0%

6‐Mercaptopurine vs methotrexate

Withdrawals due to adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether 6‐Mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.68 [0.17, 2.75]
1 study · 57 participants
Very low

Azathioprine or 6‐mercaptopurine vs methotrexate

Withdrawals due to adverse events · Patients with active Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 0.78 [0.23, 2.71]
2 studies · 85 participants
Very low

Azathioprine or 6‐mercaptopurine vs 5‐ASA or Sulfasalzine

Withdrawals due to adverse events · Patients with active Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in withdrawals due to adverse events compared with 5‐ASA or Sulfasalzine (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 0.98 [0.38, 2.54]
2 studies · 156 participants
Low

Azathioprine or 6‐mercaptopurine vs placebo

Withdrawals due to adverse events · Patients with active Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 1.7 [0.94, 3.08]
8 studies · 510 participants
Moderate

Azathioprine or 6‐mercaptopurine vs placebo

Withdrawals due to adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 3.12 [1.59, 6.09]
7 studies · 661 participants
Very low

Azathioprine or 6‐mercaptopurine vs mesalazine or sulfasalazine

Withdrawals due to adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with mesalazine or sulfasalazine (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1.86 [0.87, 3.97]
2 studies · 290 participants
Very low