Findings

What do systematic reviews say?

6 questions · 6 findings · 4 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

38% silver diamine fluoride vs Atraumatic restorative treatment (ART)

Caries/restoration status in permanent molars · Children with dental caries in permanent (first) molars

SDF gave significantly better caries/restoration outcomes than ART over 9 months in children's permanent molars (p=0.004; ungraded).

1 finding from 1 review

A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent teeth. 2023 All outcomes
9 months · School-based (children) · Satyarup 2022 (school setting, India)
Satyarup et al. (2022): 38% SDF vs ART; SDF group 5.6% carious teeth with partly lost restorations vs ART 16.7% carious with partly lost and 8.9% carious with completely lost restorations (p=0.004, favoring SDF).
1 study · 190 participants
GRADE not reported

38% silver diamine fluoride vs Atraumatic restorative treatment (ART)

restoration and caries status · children with caries in permanent molars

The review reported SDF was beneficial for arresting caries; no effect estimate or GRADE rating was reported.

1 finding from 1 review

A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent teeth. 2023 All outcomes
9 months · Rohtak district Haryana India
no estimate extracted
1 study · 190 participants
GRADE not reported

38% silver diamine fluoride vs Fluoride varnish or atraumatic restorative treatment

Coronal carious lesions arrest · Children with coronal carious lesions (primary dentition)

One review reported a risk ratio of 1.66 favouring SDF over fluoride varnish or ART for arresting coronal caries in primary teeth (no CI; ungraded).

1 finding from 1 review

Silver diamine fluoride for managing carious lesions: an umbrella review. 2019 All outcomes
Primary dentition
RR 1.66
2 studies
GRADE not reported

Silver diamine fluoride (SDF; 30% or 38%) vs Atraumatic restorative treatment (ART)

Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars

SDF was not significantly better than ART at arresting caries (pooled ES 0.05, 95% CI -0.42 to 0.51; ungraded).

1 finding from 1 review

Silver Diamine Fluoride (SDF) Efficacy in Arresting Cavitated Caries Lesions in Primary Molars: A Systematic Review… 2022 All outcomes
Pooled across 3-12 month follow-ups · Pediatric dental care in hospital, community/school and outpatient settings (Saudi Arabia, China, India, Brazil, Spain) · Comparator: SDF vs ART (moderator analysis by treatment type)
ES 0.05 [-0.42, 0.51]
2 studies · 146 participants
GRADE not reported

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)

In one trial, SDF greatly increased individual-level caries arrestment versus ART/glass ionomer cement (OR 18.03); this subgroup was not separately GRADE-rated.

1 finding from 1 review

The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… 2024 All outcomes
3 weeks to 12 months · Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified · SDF vs ART(GIC)
OR 18.03 [7.34, 44.28]
1 study · 234 participants
GRADE not reported

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)

Pooling two trials, SDF and ART/glass ionomer cement showed no clear difference in tooth-level caries arrestment (OR 1.22, wide CI; ungraded subgroup).

1 finding from 1 review

The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… 2024 All outcomes
6 to 12 months · Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified · SDF vs ART(GIC)
OR 1.22 [0.09, 16.34]
2 studies · 273 participants
GRADE not reported