What do systematic reviews say?

10 mg warfarin nomogram vs 5 mg warfarin nomogram

10 mg warfarin nomogram probably leads to higher therapeutic INR INR TEST compared with 5 mg warfarin nomogram (moderate certainty).

• Warfarin initiation nomograms for venous thromboembolism 2016 · Cochrane Headline outcomes only
  RR 1.27 [1.05, 1.54]
  3 studies · 383 participants
  Moderate

10 mg warfarin nomogram vs 5 mg warfarin nomogram

10 mg warfarin nomogram showed no clear difference in recurrent venous thromboembolism sonography or lung scan or chest… compared with 5 mg warfarin nomogram (low certainty).

• Warfarin initiation nomograms for venous thromboembolism 2016 · Cochrane Headline outcomes only
  RR 1.48 [0.39, 5.56]
  3 studies · 362 participants
  Low

10 mg warfarin nomogram vs 5 mg warfarin nomogram

10 mg warfarin nomogram showed no clear difference in major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or… compared with 5 mg warfarin nomogram (moderate certainty).

• Warfarin initiation nomograms for venous thromboembolism 2016 · Cochrane Headline outcomes only
  RR 0.97 [0.27, 3.51]
  4 studies · 494 participants
  Moderate

10 mg warfarin nomogram vs 5 mg warfarin nomogram

It is very uncertain whether 10 mg warfarin nomogram changes minor bleeding it is not major bleeding compared with 5 mg warfarin nomogram (very low certainty).

• Warfarin initiation nomograms for venous thromboembolism 2016 · Cochrane Headline outcomes only
  RR 0.52 [0.15, 1.83]
  2 studies · 243 participants
  Very low

10 mg warfarin nomogram vs 5 mg warfarin nomogram

• Warfarin initiation nomograms for venous thromboembolism 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 111 participants
  Low