What do systematic reviews say?

Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

FEV1 % predicted · children and adolescents with cystic fibrosis

FVC · children and adolescents with cystic fibrosis

Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Growth and nutritional status · children and adolescents with cystic fibrosis

Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · children and adolescents with cystic fibrosis

Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · children and adolescents with cystic fibrosis

Adverse effects of antibiotics: number of participants reporting a serious adverse event · children and adolescents with cystic fibrosis

Eradication of P aeruginosa from the respiratory tract: number of participants testing negative for P aeruginosa at 3 months and remaining free until 15 months · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Eradication of P aeruginosa from the respiratory tract: time to next isolation of P aeruginosa from BAL, sputum or oropharyngeal cultures · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Severe intraventricular haemorrhage · neonates with sepsis

Periventricular leukomalacia · neonates with sepsis

Length of stay among survivors · neonates with sepsis

Retinopathy of prematurity · neonates with sepsis

Chronic lung disease in survivors · neonates with sepsis

Severe intraventricular haemorrhage · neonates with sepsis

Periventricular leukomalacia · neonates with sepsis

Length of stay among survivors · neonates with sepsis

Retinopathy of prematurity · neonates with sepsis