What do systematic reviews say?

Adverse events · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain)

Adverse events · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…

Adverse events · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)

Adverse events · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)

Adverse events · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)

Adverse events · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)

Adverse events · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)

Adverse events · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

Adverse events · People with dental caries in primary teeth (mainly children)

Adverse events · Children with carious primary teeth

Adverse events · Older adults with root caries in permanent (mature) teeth (mean age 75 years)

Adverse events · Adults (16 years or over) with one or more defective resin composite restoration(s) in a molar or premolar tooth/teeth

Adverse events · Adults (16 years or over) with one or more defective amalgam restoration(s) in a molar or premolar tooth/teeth

Adverse events · Children aged 4 to 12 years attending primary school

Adverse events (any type) and safety of sealant · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer