What do systematic reviews say?

Sesame oil vs Chlorhexidine mouthwash

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Asokan 2011 (2-arm trial) compared sesame oil versus chlorhexidine 0.2% mouthwash (OLT and BANA test). We could not include the results in the meta-analysis because they did not report post-intervention OLT score and P…
  1 study
  GRADE not reported

0.6% eucalyptus chewing gum vs Placebo chewing gum

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 4 weeks
  Patient-reported OLT score: listed in the Summary of findings table but no data reported. No data were reported for patient-reported OLT score.
  0 studies
  No studies found

Scaling and root planing (SRP) plus glycine powder air polishing vs Scaling/root planing alone

Scaling and root planing (SRP) plus glycine powder air polishing showed no clear difference in volatile sulphur compounds (VSC), halimeter compared with scaling and root planing (SRP) alone; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  30 days
  MD -3.87 [-17.93, 10.19]
  1 study · 60 participants
  GRADE not reported

Hinokitiol gel vs Placebo gel

It is very uncertain whether hinokitiol gel changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo gel (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 4 weeks
  MD -0.27 [-1.26, 0.72]
  1 study · 18 participants
  Very low

1000 mg champignon extract vs placebo

1000 mg champignon extract showed no clear difference in patient's family member-reported VAS score (scale 0 to 100) compared with placebo; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  MD -1.74 [-15.52, 12.04]
  1 study · 40 participants
  GRADE not reported

Hinokitiol gel vs Placebo gel

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 4 weeks
  Patient-reported OLT score: listed in the Summary of findings table but no data reported. No data were reported for patient-reported OLT score.
  0 studies
  No studies found

1000 mg champignon extract vs 50 mg champignon extract

It is very uncertain whether 1000 mg champignon extract changes patient-reported visual analogue scale (VAS) score (scale 0 to 100) compared with 50 mg champignon extract (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 2 weeks
  MD -5.32 [-18.14, 7.5]
  1 study · 40 participants
  Very low

1000 mg champignon extract vs placebo

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 2 weeks
  Dentist-reported OLT score: listed in the Summary of findings table but no data reported. No data were reported for dentist-reported OLT score.
  0 studies
  No studies found

0.6% eucalyptus chewing gum vs Placebo chewing gum

It is very uncertain whether 0.6% eucalyptus chewing gum changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo chewing gum (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 4 weeks
  MD -0.1 [-0.31, 0.11]
  1 study · 65 participants
  Very low

0.6% eucalyptus chewing gum vs 0.4% eucalyptus chewing gum

0.6% eucalyptus chewing gum showed no clear difference in volatile sulphur compounds (VSC) compared with 0.4% eucalyptus chewing gum; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  4 weeks
  MD 0.0 [-0.21, 0.21]
  1 study · 64 participants
  GRADE not reported

Pycnogenol chewing gum vs Placebo chewing gum

Pycnogenol chewing gum led to lower VSC: hydrogen sulphide compared with placebo chewing gum; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  4 weeks
  MD -114.9 [-206.59, -23.21]
  1 study · 21 participants
  GRADE not reported

Miswak (Salvadora persica) stick vs Chlorhexidine mouthwash

It is very uncertain whether miswak (Salvadora persica) stick changes patient self-assessment VAS (scale 0 to 10) compared with chlorhexidine mouthwash (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 1 week
  MD -0.26 [-1.16, 0.64]
  1 study · 24 participants
  Very low

Pycnogenol chewing gum vs Placebo chewing gum

Pycnogenol chewing gum showed no clear difference in VSC: methyl mercaptan compared with placebo chewing gum; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  4 weeks
  MD -8.4 [-24.95, 8.15]
  1 study · 21 participants
  GRADE not reported

Pycnogenol chewing gum vs Placebo chewing gum

Pycnogenol chewing gum showed no clear difference in VSC: methyl sulphide compared with placebo chewing gum; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  4 weeks
  MD -4.7 [-27.01, 17.61]
  1 study · 21 participants
  GRADE not reported

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

It is very uncertain whether mechanical tongue cleaning (tongue scraper) changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with no tongue cleaning (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 2 weeks
  MD -0.2 [-0.34, -0.07]
  2 studies · 46 participants
  Very low

Miswak (Salvadora persica) stick vs Chlorhexidine mouthwash

It is very uncertain whether miswak (Salvadora persica) stick changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with chlorhexidine mouthwash (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 1 week
  MD -0.55 [-1.33, 0.23]
  1 study · 24 participants
  Very low

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

Mechanical tongue cleaning (tongue scraper) showed no clear difference in volatile sulphur compounds (VSC) compared with no tongue cleaning; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  1 week
  MD -7.69 [-47.08, 31.69]
  2 studies · 46 participants
  GRADE not reported

Hinokitiol gel vs Placebo gel

Hinokitiol gel showed no clear difference in VSC: hydrogen sulphide compared with placebo gel; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  28 days
  MD -2.13 [-5.33, 1.08]
  1 study · 18 participants
  GRADE not reported

1000 mg champignon extract vs 50 mg champignon extract

1000 mg champignon extract showed no clear difference in patient's family member-reported VAS score (scale 0 to 100) compared with 50 mg champignon extract; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  MD -0.61 [-15.58, 14.36]
  1 study · 40 participants
  GRADE not reported

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (mean worst ability to eat, 1 to 4 scale) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes

  BMT/SCT after conditioning for haematological cancers
  MD -0.50 [-1.21, 0.21]
  1 study · 42 participants
  GRADE not reported