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Evidence found and GRADE certainty

212 questions · 218 findings · 11 reviews · Temporomandibular disorders and sleep · related questions CL0289

No studies found 56 · 25.7%GRADE not reported 135 · 61.9%Very low 27 · 12.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Oral celecoxib (COX-2 inhibitor) vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral celecoxib (COX-2 inhibitor) showed no clear difference in pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Maximum pain while on medication (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in maximum pain while on medication (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Naproxen vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral naproxen (NSAID) led to lower pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Tenderness on palpation of three or more masticatory muscles · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in tenderness on palpation of three or more masticatory muscles compared with placebo; GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Severe or very severe symptoms · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in severe or very severe symptoms compared with placebo; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Present pain of TMD (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in present pain of TMD (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral diazepam vs placebo

Number of participants with severe dysfunction (pain of TMD not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diazepam (benzodiazepine) showed no clear difference in number of participants with severe dysfunction (pain of TMD not… compared with placebo; GRADE not reported.

1 finding from 1 review

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Development of TMD (onset/incidence of signs and symptoms) · People without TMD at baseline undergoing orthodontic treatment (TMD clinically absent at baseline); no age restriction provided follow-up…

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Overall symptoms, pain and headache (relief from symptoms assessed by global measures) · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Daily pain (not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in daily pain (not improved) compared with placebo; GRADE not reported.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Overall success (compound score combining pain and MIO) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage showed no clear difference in overall success (compound score combining pain and MIO) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Temporomandibular joint tenderness · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

The review found no eligible studies for this question.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Deviation of the mandible · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

The review found no eligible studies for this question.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Pain (VAS) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage showed no clear difference in pain (VAS) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Trismus / maximum mouth opening (mean) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage led to lower maximum incisal (mouth) opening (MIO) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Improvement in pain (proportion of participants improved/healed) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage showed no clear difference in improvement in pain (proportion of participants improved/healed) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Palatal splint

Total sleep time, next night; · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in total sleep time (min) compared with palatal splint; GRADE not reported.

1 finding from 1 review