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Evidence found and GRADE certainty

741 questions · 808 findings · 27 reviews · Oral medicine and oral cancer · related questions CL0289

No studies found 95 · 11.8%GRADE not reported 498 · 61.6%Very low 134 · 16.6%Low 53 · 6.6%Moderate 27 · 3.3%High 1 · 0.1%

Clobetasol propionate ointment vs Low-level laser therapy (LLLT)

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether clobetasol propionate ointment changes pain (mean score) compared with low-level laser therapy (LLLT) (very low certainty).

1 finding from 1 review

Clobetasol propionate 0.025% microspheres vs Clobetasol propionate 0.025% ointment

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate 0.025% microspheres showed no clear difference in clinical score compared with clobetasol propionate 0.025% ointment; GRADE not reported.

1 finding from 1 review

Clobetasol propionate ointment vs Low-level laser therapy (LLLT)

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether clobetasol propionate ointment changes clinical score compared with low-level laser therapy (LLLT) (very low certainty).

1 finding from 1 review

Topical triamcinolone acetonide vs pimecrolimus 1%

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean VAS score) compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs Photodynamic therapy

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes pain (mean score) compared with photodynamic therapy (very low certainty).

1 finding from 1 review

Clobetasol propionate ointment vs Clobetasol propionate 0.025% ointment

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate 0.05% ointment showed no clear difference in pain (mean score) compared with clobetasol propionate 0.025% ointment (low certainty).

1 finding from 1 review

Clobetasol propionate ointment vs Low-level laser therapy (LLLT)

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether clobetasol propionate ointment changes clinical resolution compared with low-level laser therapy (LLLT) (very low certainty).

1 finding from 1 review

Clobetasol propionate ointment vs Triamcinolone acetonide ointment

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate ointment may leads to higher clinical resolution compared with triamcinolone acetonide ointment (low certainty).

1 finding from 1 review

0.6% eucalyptus chewing gum vs 0.4% eucalyptus chewing gum

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether 0.6% eucalyptus chewing gum changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with 0.4% eucalyptus chewing gum (very low certainty).

1 finding from 1 review

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

Patient-reported OLT score · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    mean 2 weeks
    Patient-reported OLT score assessed with patient's perception: listed in the Summary of findings table but no data reported. No data were reported for patient-reported OLT score.
    0 studies
    No studies found

0.6% eucalyptus chewing gum vs Placebo chewing gum

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

0.6% eucalyptus chewing gum showed no clear difference in volatile sulphur compounds (VSC) compared with placebo chewing gum; GRADE not reported.

1 finding from 1 review

Miswak (Salvadora persica) stick vs Chlorhexidine mouthwash

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Miswak (Salvadora persica) stick led to lower volatile sulphur compounds (VSC) compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Hinokitiol gel vs Placebo gel

VSC: methyl mercaptan · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Hinokitiol gel showed no clear difference in VSC: methyl mercaptan compared with placebo gel; GRADE not reported.

1 finding from 1 review

Topical G32 (ayurvedic preparation) vs Chlorhexidine, 0.2% to 2% (solution or gel)

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Topical G32 (ayurvedic preparation) showed no clear difference in volatile sulphur compounds (VSC) compared with chlorhexidine digluconate 1% gel; GRADE not reported.

1 finding from 1 review

1000 mg champignon extract vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether 1000 mg champignon extract changes patient-reported visual analogue scale (VAS) score (scale 0 to 100) compared with placebo (very low certainty).

1 finding from 1 review