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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)

Patient discomfort · People with temporomandibular disorders (TMD)

The review found no eligible studies for this question.

1 finding from 1 review
  • Listed in Summary of findings 1 as 'Not reported'; this outcome was not reported by any included study for this comparison. Discomfort was not reported in any included study across the whole review.
    0 studies
    No studies found

Facemask with rapid maxillary expansion (RME) vs Facemask with alternating rapid maxillary expansion and constriction (Alt-RAMEC)

A-Nasion perpendicular (A-NPerp) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask with rapid maxillary expansion (RME) led to higher A-Nasion perpendicular (A-NPerp) compared with facemask with alternating rapid maxillary expansion and constriction…; GRADE not reported.

1 finding from 1 review

Facemask with rapid maxillary expansion (RME) vs Tongue appliance

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask with rapid maxillary expansion (RME) showed no clear difference in ANB compared with tongue appliance; GRADE not reported.

1 finding from 1 review

Facemask with rapid maxillary expansion (RME) vs Modified tandem appliance

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask with rapid maxillary expansion (RME) showed no clear difference in ANB compared with modified tandem appliance; GRADE not reported.

1 finding from 1 review

Superelastic NiTi arch wire vs Thermoelastic NiTi arch wire

Root resorption · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

It is very uncertain whether superelastic NiTi arch wire changes root resorption (reduction in root length) compared with thermoelastic NiTi arch wire (very low certainty).

1 finding from 1 review

Surgically-anchored orthodontic treatment (miniplates) vs no intervention

Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

The review found no eligible studies for this question.

1 finding from 1 review

Spirulina vs Oxitard (antioxidant)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Spirulina may leads to lower maximal mouth opening (interincisal distance) compared with oxitard (antioxidant) (low certainty).

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Depression · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in depression compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Orthodontic removable traction appliance (ORTA) vs no intervention

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Orthodontic removable traction appliance (ORTA) led to higher overjet compared with untreated control (no treatment); GRADE not reported.

1 finding from 1 review

Superelastic NiTi arch wire vs Thermoelastic NiTi arch wire

Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Superelastic NiTi arch wire showed no clear difference in time to next/working arch wire compared with thermoelastic NiTi arch wire; GRADE not reported.

1 finding from 1 review

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

Pain at 24 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem traction bow, mandibular headgear, ORTA, reverse Twin Block, Reverse Forsus) vs no treatment

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem… led to higher wits appraisal compared with no treatment; GRADE not reported.

1 finding from 1 review

Intralesional steroid injections vs Alternative medicinal treatments

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Intralesional steroid injections showed no clear difference in maximal mouth opening (interincisal distance) compared with alternative medicinal treatments (low certainty).

2 findings from 1 review

Surgery plus Heister jaw opener vs Surgery plus wooden tongue depressors

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether surgery plus Heister jaw opener changes maximal mouth opening (interincisal distance) compared with surgery plus wooden tongue depressors (very low certainty).

2 findings from 1 review

Occlusal splint vs Another occlusal splint with a different mechanism of action

Frequency of joint noise · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes frequency of joint noise compared with another occlusal splint with a different mechanism of action (very low certainty).

1 finding from 1 review