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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · Oral Health · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics

Number of ibuprofen tablets required · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)

Postoperative systemic antibiotics… showed no clear difference in number of ibuprofen tablets required compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.

1 finding from 1 review

Orthodontic removable traction appliance (ORTA) vs no intervention

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Orthodontic removable traction appliance (ORTA) led to higher wits appraisal compared with untreated control (no treatment); GRADE not reported.

1 finding from 1 review

Facemask (with frame internal fixation) vs Frankel III functional appliance

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask (with frame internal fixation) showed no clear difference in wits appraisal compared with frankel III functional appliance; GRADE not reported.

1 finding from 1 review

Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)

Joint pain at rest · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes joint pain at rest compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).

1 finding from 1 review

Intralesional steroid injection plus adjunctive treatment vs steroid injection

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Intralesional steroid injection plus adjunctive treatment showed no clear difference in maximal mouth opening (interincisal distance) compared with intralesional steroid injection alone (low certainty).

2 findings from 1 review

Topical curcumin gel vs Topical aloe vera gel

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether topical curcumin gel changes maximal mouth opening (interincisal distance) compared with topical aloe vera gel (very low certainty).

1 finding from 1 review

Commercial fluoride-releasing RMGIC orthodontic adhesive (Fuji Ortho LC) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Fluoride ion release · Human enamel specimens around orthodontic brackets (in vitro)

In vitro, the commercial RMGIC Fuji Ortho LC showed significant fluoride release up to 6 months in a single study (ungraded).

1 finding from 1 review

Mandibular headgear vs no intervention

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
1 finding from 1 review

Reverse Twin Block with lip pads and rapid maxillary expander (RME) vs no intervention

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Reverse Twin Block with lip pads and rapid maxillary expander (RME) led to higher ANB compared with untreated control (no treatment); GRADE not reported.

1 finding from 1 review

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem traction bow, mandibular headgear, ORTA, reverse Twin Block, Reverse Forsus) vs no treatment

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem… probably leads to higher overjet compared with no treatment (moderate certainty).

1 finding from 1 review

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

Swelling (mean) · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)

The review found no eligible studies for this question.

3 findings from 1 review

Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics

Percussion pain at 24 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)

Postoperative systemic antibiotics… showed no clear difference in percussion pain at 24 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.

2 findings from 1 review

Buccal fat pad pedicle plus placental extract vs Buccal fat pad pedicle alone

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether buccal fat pad pedicle plus placental extract changes maximal mouth opening (interincisal distance) compared with buccal fat pad pedicle alone (very low certainty).

1 finding from 1 review

Surgically-anchored orthodontic treatment (miniplates) vs no intervention

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Surgically-anchored orthodontic treatment (miniplates) may leads to higher overjet compared with untreated control (no treatment) (low certainty).

1 finding from 1 review

Facemask vs no intervention

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask led to higher overjet compared with untreated control (no treatment); GRADE not reported.

3 findings from 1 review