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Evidence found and GRADE certainty

486 questions · 503 findings · 36 reviews · Oral and maxillofacial surgery · related questions CL0289

No studies found 116 · 23.1%GRADE not reported 303 · 60.2%Very low 66 · 13.1%Low 12 · 2.4%Moderate 2 · 0.4%High 4 · 0.8%

Resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Limitation of movement · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Aesthetics assessed by dentist: interproximal papilla dimension · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to lower aesthetics assessed by dentist: interproximal papilla dimension compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Implant failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to lower implant failure compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Major complication at augmented site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower major complications at the augmented site compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Open reduction and fixation vs Closed (conservative) management (no active intervention other than soft diet, analgesics or antibiotics; or intermaxillary/maxillary-mandibular fixation with rigid or elastic traction)

Outcome not reported · Adults, over 18 years of age, with unilateral or bilateral fractures of the mandibular condyles

The review found no eligible studies for this question.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Aesthetics assessed by dentist: position of the perimplant tissues · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to higher aesthetics assessed by dentist: position of the perimplant tissues compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Oral propranolol vs placebo

Reduction in pain duration (percentage of day) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral propranolol (beta-blocker) showed no clear difference in reduction in pain duration (percentage of day) compared with placebo; GRADE not reported.

1 finding from 1 review

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Implant failure · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site led to lower implant failure compared with no augmentation; GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Patients' aesthetic perception (satisfaction with crown appearance) · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… showed no clear difference in patients' aesthetic perception (satisfaction with crown appearance) compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Participants' assessment of improvement of pain in left TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in participants' assessment of improvement of pain in left TMJ (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Pain on palpation of left masseter muscle (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in pain on palpation of left masseter muscle (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Immediate-delayed implants (placed within 8 weeks after tooth extraction)

Aesthetics assessed by dentist: position of the perimplant tissues · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed just after tooth extraction) showed no clear difference in aesthetics assessed by dentist: position of the perimplant tissues compared with immediate-delayed implants (placed within 8 weeks after tooth…; GRADE not reported.

1 finding from 1 review

Piroxicam vs placebo

Number of participants with severe dysfunction (pain of TMD not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral piroxicam (NSAID) showed no clear difference in number of participants with severe dysfunction (pain of TMD not… compared with placebo; GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Aesthetics · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower poor aesthetics measured by dentist (after restoration) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Pain on daily activity (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in pain on daily activity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral celecoxib (COX-2 inhibitor) vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral celecoxib (COX-2 inhibitor) showed no clear difference in pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review