What do systematic reviews say?

26 questions · 26 findings · 2 reviews · Pain, Palliative and Supportive Care · related questions CL0289

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No studies found 9 · 34.6%GRADE not reported 10 · 38.5%Very low 5 · 19.2%Low 2 · 7.7%Moderate 0 · 0%High 0 · 0%

Perioperative infraorbital nerve block vs Intravenous analgesia

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · Children up to 13 years of age, undergoing cleft lip repair surgery

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
Not pooled (lack of data). Delgado 2005: longer in the infraorbital block group (7.3 +/- 5.1 hours) versus intravenous analgesia (2.8 +/- 2.2 hours) (P < 0.01). Simion 2008: no significant difference (195.32 +/- 71.21…
3 studies
GRADE not reported

Pilocarpine vs placebo

Xerostomia (dry mouth relief) · Patients with radiation-induced salivary gland dysfunction

1 finding from 1 review

Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
Johnson 1993: positive response (>25 mm change in VAS score) in 25% of participants on placebo, 51% on pilocarpine 5 mg tds, 47% on pilocarpine 10 mg tds. LeVeque 1993: positive response in 7% on placebo vs 42% on…
2 studies · 278 participants
GRADE not reported

Parasympathomimetic drugs (choline esters, cholinesterase inhibitors) vs No treatment

Outcome not reported · Patients with radiation-induced salivary gland dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pilocarpine vs placebo

Other oral symptoms (oral discomfort, dysphonia) · Patients with radiation-induced salivary gland dysfunction

1 finding from 1 review

Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
Both studies assessed oral discomfort and dysphonia (Johnson 1993; LeVeque 1993); pilocarpine reported to improve associated symptoms of salivary gland dysfunction (oral discomfort, dysphonia). No pooled data.
2 studies · 278 participants
GRADE not reported

Pilocarpine vs Artificial saliva

Other oral symptoms (dysgeusia, dysphagia) · Patients with radiation-induced salivary gland dysfunction

1 finding from 1 review

Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
Davies 1994 assessed dysgeusia and dysphagia; pilocarpine reported more effective than mucin-based artificial saliva for dysgeusia. No pooled data.
1 study · 20 participants
GRADE not reported

Pilocarpine vs Artificial saliva

Dry mouth (xerostomia) · Patients with radiation-induced salivary gland dysfunction

1 finding from 1 review

Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
Davies 1994 (cross-over, 20 participants): mean improvement in VAS score 22.5 mm with pilocarpine vs 15.2 mm with artificial saliva (100 mm scale). The improvement was greater with pilocarpine but was not statistically…
1 study · 20 participants
GRADE not reported