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What do systematic reviews say?

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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Ionic powered toothbrush vs Powered toothbrush with a different mode of action

Outcome not reported · People of any age with no reported disability affecting their ability to practise normal self-toothbrushing; individuals wearing…

The review found no eligible studies for this question.

1 finding from 1 review

Radiotherapy (morning) vs Afternoon radiotherapy

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Morning radiotherapy showed no clear difference in total mortality compared with afternoon radiotherapy; GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Implant failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to lower implant failure compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Major complication at augmented site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower major complications at the augmented site compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Hyperfractionated/accelerated/split-course radiotherapy vs Conventional (standard) fractionation radiotherapy

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Open reduction and fixation vs Closed (conservative) management (no active intervention other than soft diet, analgesics or antibiotics; or intermaxillary/maxillary-mandibular fixation with rigid or elastic traction)

Outcome not reported · Adults, over 18 years of age, with unilateral or bilateral fractures of the mandibular condyles

The review found no eligible studies for this question.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Aesthetics assessed by dentist: position of the perimplant tissues · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to higher aesthetics assessed by dentist: position of the perimplant tissues compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Oral propranolol vs placebo

Reduction in pain duration (percentage of day) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral propranolol (beta-blocker) showed no clear difference in reduction in pain duration (percentage of day) compared with placebo; GRADE not reported.

1 finding from 1 review

GM-CSF vs placebo or no treatment

Improvement in mucositis · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Granulocyte macrophage-colony stimulating factor (GM-CSF) led to higher improvement in mucositis compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Split‐course radiotherapy (8 fractions, 30 Gy) vs Accelerated radiotherapy

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Split-course radiotherapy showed no clear difference in total mortality compared with accelerated radiotherapy; GRADE not reported.

1 finding from 1 review

Mixed beam (neutron and photon) radiotherapy vs Conventional photon radiotherapy

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Mixed beam (neutron and photon) radiotherapy showed no clear difference in total mortality compared with conventional photon radiotherapy; GRADE not reported.

1 finding from 1 review

Powered toothbrush, counter oscillation action vs Circular powered toothbrush

Plaque (level reduction) · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)
1 finding from 1 review
  • Different powered toothbrushes for plaque control and gingival health 2010 · Cochrane All outcomes
    Short term (1-3 months) · Adolescents
    Trimpeneers 1997 reported a significant difference in favour of the counter oscillation brush for plaque index at 2 months over a circular mode of action brush; data were unsuitable for meta-analysis.
    1 study · 36 participants
    GRADE not reported

Screening for domestic violence vs No screening

Proportion of victims of domestic violence detected by self report · Adults (16 years of age and older) who present to any healthcare setting with dental or facial injury

The review found no eligible studies for this question.

1 finding from 1 review

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Implant failure · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site led to lower implant failure compared with no augmentation; GRADE not reported.

1 finding from 1 review

Powered toothbrush, counter oscillation action vs Rotation oscillation powered toothbrush

Plaque (level reduction) · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)
1 finding from 1 review
  • Different powered toothbrushes for plaque control and gingival health 2010 · Cochrane All outcomes
    Short term (1-3 months) · Adolescents
    One cross-over trial of 36 adolescents (Trimpeneers 1997); data not presented in a suitable format for meta-analysis; no significant differences between counter oscillation and rotation oscillation for plaque index /…
    1 study · 36 participants
    GRADE not reported

Intensity modulated radiotherapy (IMRT) vs Conventional or other radiotherapy

Outcome not reported · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

The review found no eligible studies for this question.

1 finding from 1 review