What do systematic reviews say?

59 questions · 60 findings · 2 reviews · related questions CL0289

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No studies found 0 · 0%GRADE not reported 41 · 68.3%Very low 9 · 15%Low 7 · 11.7%Moderate 3 · 5%High 0 · 0%

Endoflas chlorophenol free (Endoflas-CF) vs Zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Endoflas chlorophenol free (Endoflas-CF) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 1.33 [0.35, 5.03]
1 study
GRADE not reported

Mineral trioxide aggregate (MTA) vs simvastatin

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
No radiological failure in any participant; not estimable
1 study · 160 participants
GRADE not reported

3Mixtatin vs simvastatin

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
No radiological failure in any participant; not estimable
1 study · 160 participants
GRADE not reported

Glutaraldehyde + zinc oxide and eugenol (ZOE) vs Full strength formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + zinc oxide and eugenol (ZOE) showed no clear difference in radiological failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
3 months
RR 0.46 [0.09, 2.28]
1 study · 48 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
No radiological failure in any participant (Aminabadi 2016); not estimable
1 study · 160 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Calcium hydroxide + sodium hypochlorite (NaOCl)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in radiological failure compared with calcium hydroxide + sodium hypochlorite (NaOCl); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.09 [0.01, 1.58]
1 study · 62 participants
GRADE not reported

Electrosurgery vs Calcium-enriched mixture (CEM)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Electrosurgery showed no clear difference in radiological failure compared with calcium-enriched mixture (CEM); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.50 [0.10, 2.61]
1 study · 102 participants
GRADE not reported

Endoflas (CH + ZOE + iodoform) vs Zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Endoflas (CH + ZOE + iodoform) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.26 [0.05, 1.50]
2 studies · 80 participants
Moderate

Acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
up to 24 months
No radiological failure in any participant; not estimable
1 study · 40 participants
GRADE not reported

Aloe vera vs Mineral trioxide aggregate (MTA)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Aloe vera led to higher radiological failure compared with mineral trioxide aggregate (MTA); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 28.00 [4.07, 192.79]
1 study · 60 participants
GRADE not reported

Portland cement (PC) vs Full strength formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Portland cement (PC) showed no clear difference in radiological failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.80 [0.23, 2.73]
1 study · 70 participants
GRADE not reported

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Non-rinse conditioner + acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes radiological failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 7.00 [0.38, 127.33]
1 study · 40 participants
Very low

Mineral trioxide aggregate (MTA) vs Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in radiological failure compared with mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 0.33 [0.01, 7.88]
1 study · 62 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Ferric sulphate (FS)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in radiological failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.58 [0.25, 1.36]
3 studies · 130 participants
Low

Self-etch adhesive + acetone-based total-etch adhesive vs Total-etching 36% phosphoric acid + acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes radiological failure compared with total-etching 36% phosphoric acid + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.33 [0.04, 2.94]
1 study · 40 participants
Very low

Sodium hypochlorite (NaOCl) vs 1:5 diluted formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Sodium hypochlorite (NaOCl) showed no clear difference in radiological failure compared with 1:5 diluted formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.86 [0.52, 6.59]
2 studies · 150 participants
GRADE not reported

Zinc oxide and eugenol (ZOE) vs Formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Zinc oxide and eugenol (ZOE) showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 1.67 [0.71, 3.89]
1 study · 50 participants
GRADE not reported

Non-rinse conditioner + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether non-rinse conditioner + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 3.00 [0.13, 69.52]
1 study · 40 participants
Very low

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Radiological failure (periapical radiolucency) after at least 1 year · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

Single-visit root canal treatment showed no clear difference in radiological failure (periapical radiolucency) after at least 1 year compared with multiple-visit root canal treatment (two or more visits) (moderate certainty).

1 finding from 1 review

Single versus multiple visits for endodontic treatment of permanent teeth 2022 · Cochrane All outcomes
At least 1 year (range 1 to 5 years)
RR 0.93 [0.81, 1.07]
13 studies · 1505 participants
Moderate