What do systematic reviews say?

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Periodontal treatment (subgingival SRP with or without other… led to lower pocket probing depth (PPD) compared with no treatment (no periodontal treatment); GRADE not reported.

• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Long term · People diagnosed with periodontitis and other cardiovascular diseases except hypertension
  MD -1.94 [-2.35, -1.53]
  1 study · 48 participants
  GRADE not reported

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling

Intensive periodontal treatment (subgingival SRP with or without… led to lower pocket probing depth (PPD) compared with supra-gingival scaling; GRADE not reported.

• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Long term · People diagnosed with periodontitis
  MD -18.90 [-26.34, -11.46]
  1 study
  GRADE not reported
• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Short term · People diagnosed with periodontitis
  MD -11.47 [-18.54, -4.40]
  1 study
  GRADE not reported
• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Short term · People diagnosed with periodontitis and hypertension
  MD -0.55 [-0.70, -0.40]
  1 study
  GRADE not reported

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Periodontal treatment (subgingival instrumentation, with or without… led to lower probing pocket depth (PPD/PD) compared with no active intervention/usual care; GRADE not reported.

• Treatment of periodontitis for glycaemic control in people with diabetes mellitus 2022 · Cochrane All outcomes

  3-4 months
  MD -0.56 [-0.72, -0.40]
  21 studies
  GRADE not reported

Enamel matrix derivative (EMD; Emdogain) vs Guided tissue regeneration (GTR) with barriers

Enamel matrix derivative (EMD; Emdogain) showed no clear difference in change in probing pocket depth (PPD) compared with guided tissue regeneration (GTR) with barriers (low certainty).

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  MD -0.4 [-1.1, 0.2]
  6 studies · 304 participants
  Low

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing pocket depth (PPD) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  MD 0.88 [0.44, 1.31]
  9 studies · 371 participants
  Low

Enamel matrix derivative (EMD; Emdogain) vs Various bone grafting (BG) procedures (animal-derived or synthetic bone / bioactive ceramic filler)

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  No statistically significant differences (one trial, Leknes 2009).
  1 study
  GRADE not reported