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Evidence found and GRADE certainty

27 questions · 39 findings · 1 reviews · Oral medicine and oral cancer · related questions CL0289

No studies found 0 · 0%GRADE not reported 6 · 15.4%Very low 22 · 56.4%Low 10 · 25.6%Moderate 1 · 2.6%High 0 · 0%

Physiotherapy (tongue-spatula jaw exercises) vs No active treatment (control)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether physiotherapy (tongue-spatula jaw exercises) changes maximal mouth opening (interincisal distance) compared with no active treatment (very low certainty).

1 finding from 1 review

Intralesional steroid injection plus adjunctive treatment vs steroid injection

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Intralesional steroid injection plus adjunctive treatment showed no clear difference in maximal mouth opening (interincisal distance) compared with intralesional steroid injection alone (low certainty).

2 findings from 1 review

Topical curcumin gel vs Topical aloe vera gel

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether topical curcumin gel changes maximal mouth opening (interincisal distance) compared with topical aloe vera gel (very low certainty).

1 finding from 1 review

Buccal fat pad pedicle plus placental extract vs Buccal fat pad pedicle alone

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether buccal fat pad pedicle plus placental extract changes maximal mouth opening (interincisal distance) compared with buccal fat pad pedicle alone (very low certainty).

1 finding from 1 review

Vasodilator vs Placebo or no active treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether vasodilators (isoxsuprine, xanthinol nicotinate) changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).

2 findings from 1 review

Buccal fat pad graft vs Extended nasolabial flap

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether buccal fat pad graft changes maximal mouth opening (interincisal distance) compared with extended nasolabial flap (very low certainty).

3 findings from 1 review

Pentoxifylline vs multivitamin and mineral supplement

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Rajendran 2006 (pentoxifylline 14 vs multivitamins 15): reported increased interincisal distance in the pentoxifylline group but no baseline data, so change could not be determined; excluded from meta-analysis.
    1 study · 29 participants
    GRADE not reported

Oxitard (antioxidant) vs Topical aloe vera gel

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Oxitard (antioxidant) may leads to higher maximal mouth opening (interincisal distance) compared with aloe vera gel (low certainty).

1 finding from 1 review

Spirulina vs Oxitard (antioxidant)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Spirulina may leads to lower maximal mouth opening (interincisal distance) compared with oxitard (antioxidant) (low certainty).

1 finding from 1 review

Intralesional steroid injections vs Alternative medicinal treatments

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Intralesional steroid injections showed no clear difference in maximal mouth opening (interincisal distance) compared with alternative medicinal treatments (low certainty).

2 findings from 1 review

Surgery plus Heister jaw opener vs Surgery plus wooden tongue depressors

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether surgery plus Heister jaw opener changes maximal mouth opening (interincisal distance) compared with surgery plus wooden tongue depressors (very low certainty).

2 findings from 1 review

Abdominal dermal fat graft vs Nasolabial flap

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether abdominal dermal fat graft changes maximal mouth opening (interincisal distance) compared with nasolabial flap (very low certainty).

2 findings from 1 review

Levamisole vs Antioxidant (Antoxid)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether levamisole changes maximal mouth opening (interincisal distance) compared with antioxidant (Antoxid) (very low certainty).

2 findings from 1 review

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in maximal mouth opening (interincisal distance) compared with placebo or no active treatment (low certainty).

3 findings from 1 review

Spirulina vs Topical aloe vera gel

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review

Lycopene plus intralesional betamethasone vs placebo

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Kumar 2007 (3-arm: lycopene vs lycopene+intralesional betamethasone vs placebo): appeared to show increased interincisal distance in the two active groups, but limited withdrawal information/incomplete data meant…
    1 study
    GRADE not reported

Jaw opening exercises alone vs Ultrasound plus jaw opening exercises

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether jaw opening exercises alone changes maximal mouth opening (interincisal distance) compared with ultrasound plus jaw opening exercises (very low certainty).

1 finding from 1 review

Intralesional triamcinolone vs Intralesional triamcinolone plus salvianolic acid B

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether intralesional triamcinolone changes maximal mouth opening (interincisal distance) compared with intralesional triamcinolone plus salvianolic acid B (very low certainty).

1 finding from 1 review

Intralesional dexamethasone injections vs placebo injection

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether intralesional dexamethasone injections changes maximal mouth opening (interincisal distance) compared with placebo injections (very low certainty).

2 findings from 1 review

Pentoxifylline vs Placebo or no active treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether pentoxifylline changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).

2 findings from 1 review