What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Oral Health · related questions CL0289

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 2 · 40%Moderate 1 · 20%High 0 · 0%

Superselective neck dissection vs Elective selective neck dissection

Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
36 months
Disease-free survival: Pandey 2018 reported 83% (superselective) vs 91% (selective) at median 36 months, not significant (P=0.69); unable to analyse (variable follow-up); 32 participants (1 RCT).
1 study · 32 participants
Very low

Surgery vs Radiotherapy alone

Disease-free survival · Adults with oropharyngeal cancer

Surgery showed no clear difference in disease-free survival (new disease, progression, and mortality) compared with radiotherapy alone (low certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 1.07 [0.27, 4.22]
1 study · 68 participants
Low

Sentinel node biopsy (neck dissection only if biopsy positive) vs Elective neck dissection

Disease-free survival · Adults with oral cavity or oropharyngeal cancer

Sentinel node biopsy (neck dissection only if biopsy positive) showed no clear difference in disease-free survival (new disease, progression, and mortality) compared with elective neck dissection (low certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.98 [0.90, 1.07]
1 study · 279 participants
Low

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower disease-free survival (new disease, progression, and mortality) compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.56 [0.45, 0.70]
5 studies · 954 participants
Moderate

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Disease-free survival · Adults with oral cavity cancer

It is very uncertain whether elective radical (comprehensive) neck dissection changes disease-free survival (new disease, progression, and mortality) compared with elective selective neck dissection (very low certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
5 years
HR 0.57 [0.29, 1.11]
1 study · 104 participants
Very low