What do systematic reviews say?

59 questions · 60 findings · 2 reviews · related questions CL0289

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No studies found 0 · 0%GRADE not reported 35 · 58.3%Very low 15 · 25%Low 7 · 11.7%Moderate 3 · 5%High 0 · 0%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Biodentine vs Calcium hydroxide (CH) · Clinical failure
  Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
  6 and 12 months
  RR 0.33 [0.01, 7.72]
  1 study · 62 participants
  GRADE not reported
Direct match · question page
- Endoflas chlorophenol free (Endoflas-CF) vs Zinc oxide and eugenol (ZOE) · Clinical failure
  Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
  6 months
  RR 3.00 [0.13, 68.26]
  1 study
  GRADE not reported
Direct match · question page
- Ankaferd Blood Stopper (ABS) vs Formocresol (FC) · Clinical failure
  Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
  6 and 12 months
  RR 0.33 [0.01, 7.58]
  1 study · 30 participants
  GRADE not reported
Direct match · question page
- Mineral trioxide aggregate (MTA) vs Full strength or 1:5 diluted formocresol (FC) · Clinical failure
  Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
  12 months
  RR 0.31 [0.10, 0.93]
  12 studies · 740 participants
  Moderate
Direct match · question page
- Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl) vs Calcium hydroxide + sodium hypochlorite (NaOCl) · Clinical failure
  Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
  6 and 12 months
  No clinical failure in any participant (Akcay 2014); not estimable
  1 study · 62 participants
  GRADE not reported

Glutaraldehyde + zinc oxide and eugenol (ZOE) vs Full strength formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + zinc oxide and eugenol (ZOE) showed no clear difference in clinical failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
3 months
RR 0.46 [0.04, 4.74]
1 study · 48 participants
GRADE not reported

Biodentine vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Biodentine showed no clear difference in clinical failure compared with calcium hydroxide (CH); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 0.33 [0.01, 7.72]
1 study · 62 participants
GRADE not reported

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 3.00 [0.13, 69.52]
1 study · 40 participants
Very low

Mineral trioxide aggregate (MTA) vs 3Mixtatin

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether mineral trioxide aggregate (MTA) changes clinical failure compared with 3Mixtatin (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.67 [0.12, 3.78]
1 study · 160 participants
Very low

Non-rinse conditioner + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
up to 24 months
No clinical failure in any participant (Demir 2007); not estimable
1 study · 40 participants
Very low

3Mix (ciprofloxacin + metronidazole + minocycline) vs simvastatin

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether 3Mix (ciprofloxacin + metronidazole + minocycline) changes clinical failure compared with simvastatin (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.00 [0.51, 1.95]
1 study · 160 participants
Very low

Aloe vera vs Mineral trioxide aggregate (MTA)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Aloe vera led to higher clinical failure compared with mineral trioxide aggregate (MTA); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 51.00 [3.25, 801.15]
1 study · 60 participants
GRADE not reported

Self-etch adhesive + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6, 12 and 24 months
RR 3.00 [0.13, 69.52]
1 study · 40 participants
Very low

Endoflas chlorophenol free (Endoflas-CF) vs Zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Endoflas chlorophenol free (Endoflas-CF) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 3.00 [0.13, 68.26]
1 study
GRADE not reported

Ankaferd Blood Stopper (ABS) vs Formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Ankaferd Blood Stopper (ABS) showed no clear difference in clinical failure compared with formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 0.33 [0.01, 7.58]
1 study · 30 participants
GRADE not reported

OrthoMTA vs RetroMTA

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

OrthoMTA showed no clear difference in clinical failure compared with retroMTA; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 3.13 [0.13, 74.85]
1 study · 96 participants
GRADE not reported

3Mixtatin vs simvastatin

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

3Mixtatin may leads to lower clinical failure compared with simvastatin (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.25 [0.08, 0.82]
1 study · 160 participants
Low

Electrosurgery vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Electrosurgery showed no clear difference in clinical failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.56 [0.13, 2.34]
2 studies · 50 participants
Low

Mineral trioxide aggregate (MTA) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) may leads to lower clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.17 [0.04, 0.70]
1 study · 160 participants
Low

Self-etch adhesive + acetone-based total-etch adhesive vs Total-etching 36% phosphoric acid + acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with total-etching 36% phosphoric acid + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 1.00 [0.07, 14.90]
1 study · 40 participants
Very low

Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl) vs Calcium hydroxide + sodium hypochlorite (NaOCl)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
No clinical failure in any participant (Akcay 2014); not estimable
1 study · 62 participants
GRADE not reported

ProRoot MTA vs RetroMTA

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
No clinical failure in any participant (Kang 2015); not estimable
1 study · 96 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Full strength or 1:5 diluted formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) probably leads to lower clinical failure compared with full strength or 1:5 diluted formocresol (FC) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.31 [0.10, 0.93]
12 studies · 740 participants
Moderate

Mineral trioxide aggregate (MTA) vs Portland cement (PC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in clinical failure compared with portland cement (PC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6, 12 and 24 months
RR 0.20 [0.01, 4.02]
3 studies · 130 participants
GRADE not reported

Full strength formocresol (FC) vs 1:25 diluted formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
No event in any participant (Goyal 2014); not estimable
1 study · 30 participants
GRADE not reported