What do systematic reviews say?

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing pocket depth (PPD) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  4 months (18 weeks)
  MD 0.59 [0.39, 0.79]
  1 study · 28 participants
  GRADE not reported

Enamel matrix derivative (EMD; Emdogain) vs Guided tissue regeneration (GTR) with barriers

Enamel matrix derivative (EMD; Emdogain) showed no clear difference in change in probing pocket depth (PPD) compared with guided tissue regeneration (GTR) with barriers (low certainty).

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  MD -0.4 [-1.1, 0.2]
  6 studies · 304 participants
  Low

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing pocket depth (PPD) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  MD 0.88 [0.44, 1.31]
  9 studies · 371 participants
  Low

Enamel matrix derivative (EMD; Emdogain) vs Various bone grafting (BG) procedures (animal-derived or synthetic bone / bioactive ceramic filler)

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  No statistically significant differences (one trial, Leknes 2009).
  1 study
  GRADE not reported