What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Skin · related questions CL0289

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Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus

Topical ciclosporin 1.5% gel showed no clear difference in physician Global Assessment (Thongprasom score) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 3.16 [1.00, 9.93]
1 study · 40 participants
GRADE not reported

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Relapse rate when medications stopped · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Topical clobetasol gave less stable results than ciclosporin when therapy ended and showed a higher incidence of side-effects (Conrotto 2006, n=40).
1 study · 40 participants
GRADE not reported

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Partial response (partial or complete response) · People with erosive oral lichen planus

Topical ciclosporin 1.5% gel led to higher partial response (partial or complete response) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 1.46 [1.04, 2.04]
1 study · 40 participants
GRADE not reported

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Conrotto 2006: ciclosporin - skin rashes (2), parotid swelling (1), and dyspepsia (3); clobetasol - dyspepsia (1).
1 study · 40 participants
GRADE not reported

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Participant‐reported pain relief of 50% or greater · People with erosive oral lichen planus

Topical ciclosporin 1.5% gel showed no clear difference in pain (>=50% improvement in symptoms) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 0.47 [0.17, 1.32]
1 study · 40 participants
GRADE not reported