What do systematic reviews say?

11 questions · 15 findings · 3 reviews · related questions CL0289

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No studies found 0 · 0%GRADE not reported 7 · 46.7%Very low 2 · 13.3%Low 4 · 26.7%Moderate 2 · 13.3%High 0 · 0%

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

In partial pulpotomy, MTA had significantly higher success than calcium hydroxide (OR 2.81; ungraded).

5 findings from 2 reviews · compare the 2 reviews

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months · Partial pulpotomy
OR 2.81 [1.38, 5.74]
Studies not reported
GRADE not reported
Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months · Mature teeth
OR 2.63 [1.14, 6.03]
Studies not reported
GRADE not reported
Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 2.41 [1.28, 4.51]
7 studies · 377 participants
Low

Show 2 more findings

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months · Irreversible pulpitis
OR 3.17 [1.25, 7.99]
Studies not reported
GRADE not reported
Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
1 to 3 years · Success after vital pulp therapy · Unadjusted; all treatment modalities and root maturities
OR 2.94 [1.93, 4.49]
10 studies · 900 participants
Low

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…

Mineral trioxide aggregate shows higher odds of clinical and radiographic success than calcium hydroxide (OR 3.05, 95% CI 1.70 to 5.45; ungraded subgroup analysis).

1 finding from 1 review

Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in managing… 2025 All outcomes
>=12 months · Primary or secondary dental care
OR 3.05 [1.70, 5.45]
4 studies · 311 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy

The effect of MTA versus CH after pulpotomy is uncertain (low certainty).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
1 to 2 years · Success after full or partial pulpotomy · Full or partial pulpotomy
OR 2.36 [0.47, 11.75]
6 studies · 341 participants
Low

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth

The effect of MTA versus CH in immature teeth is very uncertain (very low certainty).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
1 to 2 years · Success after vital pulp therapy · Immature teeth
OR 2.22 [0.13, 36.67]
2 studies · 106 participants
Very low

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing direct pulp capping

MTA increases clinical and radiographic success versus CH after direct pulp capping (moderate certainty).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
1 to 3 years · Success after direct pulp capping · Direct pulp capping
OR 3.10 [1.66, 5.79]
4 studies · 559 participants
Moderate

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth with mixed root development

The effect of MTA versus CH in teeth with mixed root development is very uncertain (very low certainty).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
1 to 2 years · Success after vital pulp therapy · Mixed root development
OR 1.11 [0.17, 7.11]
3 studies · 257 participants
Very low

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in mature permanent teeth

MTA increases clinical and radiographic success versus CH in mature teeth (moderate certainty).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
1 to 3 years · Success after vital pulp therapy · Mature teeth
OR 3.34 [1.81, 6.17]
5 studies · 537 participants
Moderate

Mineral trioxide aggregate (MTA) vs Biodentine

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and Biodentine have similar pulpotomy success (OR 0.89, not significant; low certainty).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 0.89 [0.47, 1.69]
6 studies · 348 participants
Low

Mineral trioxide aggregate (MTA) vs TotalFill BC

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and TotalFill BC had comparable pulpotomy success (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 1.44 [0.65, 3.19]
2 studies · 248 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Calcium-enriched mixture (CEM)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and calcium-enriched mixture had comparable pulpotomy success (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 0.78 [0.46, 1.34]
4 studies · 611 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Platelet-rich fibrin (PRF)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and platelet-rich fibrin had comparable pulpotomy success (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 1.02 [0.43, 2.43]
3 studies · 109 participants
GRADE not reported