What do systematic reviews say?

3 questions · 9 findings · 1 reviews · related questions CL0289

No studies found 0 · 0%GRADE not reported 6 · 66.7%Very low 3 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Probing pocket depth · Adults with aggressive periodontitis

Clindamycin + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.14 [-0.82, 0.54]
1 study · 26 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.10 [-0.79, 0.59]
1 study · 26 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD 0.20 [-0.38, 0.78]
1 study · 26 participants
Very low

Probing pocket depth · Adults with aggressive periodontitis

It is very uncertain whether clindamycin + SRP changes probing pocket depth compared with doxycycline + SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -0.80 [-1.58, -0.02]
1 study · 23 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.20 [-0.36, 0.76]
1 study · 23 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.40 [-1.14, 0.34]
1 study · 23 participants
GRADE not reported

Probing pocket depth · Adults with aggressive periodontitis

It is very uncertain whether clindamycin + SRP changes probing pocket depth compared with SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -1.80 [-2.47, -1.13]
1 study · 21 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -1.10 [-1.94, -0.26]
1 study · 21 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.10 [-0.55, 0.75]
1 study · 21 participants
GRADE not reported