What do systematic reviews say?

9 questions · 21 findings · 1 reviews · related questions CL0289

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No studies found 3 · 14.3%GRADE not reported 12 · 57.1%Very low 6 · 28.6%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Clindamycin + SRP vs SRP · Clinical attachment level (CAL)
  Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
  Intermediate-term (> 3 months to < 1 year)
  MD -1.30 [-2.14, -0.46]
  1 study · 21 participants
  GRADE not reported
Direct match · question page
- Clindamycin + SRP vs SRP · Probing pocket depth
  Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
  Long-term (≥ 1 year)
  MD -1.80 [-2.47, -1.13]
  1 study · 21 participants
  Very low
Direct match · question page
- Clindamycin + SRP vs SRP · Percentage of closed pockets
  Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found
Direct match · question page
- Clindamycin + SRP vs Metronidazole + SRP · Probing pocket depth
  Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
  Short-term (≤ 3 months)
  MD -0.14 [-0.82, 0.54]
  1 study · 26 participants
  GRADE not reported
Direct match · question page
- Clindamycin + SRP vs Metronidazole + SRP · Clinical attachment level (CAL)
  Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
  Short-term (≤ 3 months)
  MD 0.40 [-0.22, 1.02]
  1 study · 26 participants
  GRADE not reported

Clindamycin + SRP vs Metronidazole + SRP

Percentage of closed pockets · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Clindamycin + SRP vs Metronidazole + SRP

Probing pocket depth · Adults with aggressive periodontitis

Clindamycin + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.14 [-0.82, 0.54]
1 study · 26 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.10 [-0.79, 0.59]
1 study · 26 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD 0.20 [-0.38, 0.78]
1 study · 26 participants
Very low

Clindamycin + SRP vs Doxycycline + SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

It is very uncertain whether clindamycin + SRP changes clinical attachment level (CAL) compared with doxycycline + SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -0.90 [-1.62, -0.18]
1 study · 23 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.40 [-1.15, 0.35]
1 study · 23 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.50 [-0.26, 1.26]
1 study · 23 participants
GRADE not reported

Clindamycin + SRP vs SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Clindamycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -1.30 [-2.14, -0.46]
1 study · 21 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.40 [-0.35, 1.15]
1 study · 21 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -1.70 [-2.40, -1.00]
1 study · 21 participants
Very low

Clindamycin + SRP vs SRP

Percentage of closed pockets · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Clindamycin + SRP vs Metronidazole + SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Clindamycin + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.40 [-0.22, 1.02]
1 study · 26 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD 0.20 [-0.55, 0.95]
1 study · 26 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 0.10 [-0.60, 0.80]
1 study · 26 participants
GRADE not reported

Clindamycin + SRP vs Doxycycline + SRP

Probing pocket depth · Adults with aggressive periodontitis

It is very uncertain whether clindamycin + SRP changes probing pocket depth compared with doxycycline + SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -0.80 [-1.58, -0.02]
1 study · 23 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.20 [-0.36, 0.76]
1 study · 23 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.40 [-1.14, 0.34]
1 study · 23 participants
GRADE not reported

Clindamycin + SRP vs SRP

Probing pocket depth · Adults with aggressive periodontitis

It is very uncertain whether clindamycin + SRP changes probing pocket depth compared with SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -1.80 [-2.47, -1.13]
1 study · 21 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -1.10 [-1.94, -0.26]
1 study · 21 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.10 [-0.55, 0.75]
1 study · 21 participants
GRADE not reported

Clindamycin + SRP vs Doxycycline + SRP

Percentage of closed pockets · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found