Physician Global Assessment (surface of erosive lesions) · People with erosive oral lichen planus
1% pimecrolimus cream showed no clear difference in physician Global Assessment (surface of erosive lesions) compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Passeron 2007: 1% pimecrolimus well-tolerated, transient burning (2) during the first 2 weeks. Swift 2005: pimecrolimus - slight burning of the tip of the tongue after applying 1% pimecrolimus…
3 studies · 52 participants
GRADE not reported
Physician Global Assessment (strong improvement) · People with erosive oral lichen planus
1% pimecrolimus cream led to higher physician Global Assessment (strong improvement) compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Participant global self-assessment · People with erosive oral lichen planus
1 finding from 1 review
One study (Passeron 2007) assessed participant global self-assessment on a 5-point scale: 5/6 participants in the 1% pimecrolimus group rated their improvement as moderate or important versus 1/6 in the placebo group…
1 study · 12 participants
GRADE not reported
Clinical response ‐ complete response · People with erosive oral lichen planus
1% pimecrolimus cream showed no clear difference in complete clinical response (complete clearance) compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Relapse rate when medications stopped · People with erosive oral lichen planus
1 finding from 1 review
In Passeron 2007 (n=12), all participants who improved during treatment relapsed within 1 month of ceasing treatment.
1 study · 12 participants
GRADE not reported
Physician Global Assessment (weighted sums of ulceration, erythema, reticulation, mm2) · People with erosive oral lichen planus
1% pimecrolimus cream showed no clear difference in physician Global Assessment (weighted sums of ulceration, erythema,… compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Pain reduction (VAS) · People with erosive oral lichen planus
1% pimecrolimus cream showed no clear difference in pain reduction (VAS) compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review