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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
11 questions in 6 reviews · cluster CL0282
current versionsNo studies 1 · 9.1%Ungraded 10 · 90.9%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anticaries vaccine or antibody (DNA, recombinant protein, nanoparticle-adjuvanted, live-vector, plant-based, or passive IgY immunization) targeting S. mutans vs Control (unvaccinated / empty vector / PBS / placebo animals) Dental caries development · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant… Assessing the Efficacy and Immunogenicity of Anticaries Vaccine-A Systematic Review and Meta-Analysis. (2025) | RR 0.53 [0.46, 0.62] | NR | Ungraded |
One-step self-adhesive resin without a separate primer (GC Ortho Connect) vs Conventional multi-step adhesive systems (three-step Transbond XT; self-etch primer Transbond Plus) White spot lesion development (QLF: mineral loss, lesion area/depth, new lesions) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 2 and 4 months Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) | Horan 2023 (1 three-arm RCT, 75 patients): the one-step adhesive without primer (GC Ortho Connect) had a significantly higher WSL incidence and larger, deeper lesions than both the three-step and self-etch systems… | 1 study · 75 participants | Ungraded |
Flowable resin composite vs Fluoride-releasing resin-based sealant Development of >=1 new carious lesion (caries incidence) · Children who were regular dental attenders with caries-free first or second primary molars (public health service… Sealants for preventing dental caries in primary teeth (2022) · Cochrane | No studies reported this outcome. | 0 studies | No studies |
Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline) New dental caries development · Patients with drooling (sialorrhea) due to neurological disease · BoNT-B 2500 U vs placebo (Isaacson RCT) Oral health effects of botulinum toxin treatment for drooling: a systematic review. (2020) | RR 2.4 [0.48, 11.80] | 1 study | Ungraded |
Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline) New dental caries development · Patients with drooling (sialorrhea) due to neurological disease · BoNT-B 3500 U vs placebo (Isaacson RCT) Oral health effects of botulinum toxin treatment for drooling: a systematic review. (2020) | RR 1.4 [0.24, 8.12] | 1 study | Ungraded |
Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs Placebo Total number of new lesions over 2-month treatment period · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 2 months Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | MD -4.20 [-4.84, -3.56] | 1 study · 40 participants | Ungraded |
Fixed dental prosthesis (cantilever FDP) vs Removable dental prosthesis (RDP) Caries incidence (2 years) · Patients with a shortened dental arch (missing posterior teeth) · 2 years Interventions for replacing missing teeth: partially absent dentition (2012) · Cochrane | RR 0.43 [0.21, 0.87] | 1 study · 50 participants | Ungraded |
Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs Placebo Number of new lesions per day · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 90 days Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | MD -0.19 [-0.35, -0.03] | 1 study · 50 participants | Ungraded |
Tetracycline suspension (250 mg, held in mouth 2 minutes then swallowed, four times daily for 5 days) vs Placebo Average number of new lesions per week · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 5 days per outbreak Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | MD -0.47 [-1.34, 0.40] | 1 study | Ungraded |
Montelukast (leukotriene receptor antagonist; 10 mg daily for 1 month then alternate days for the second month) vs Placebo Total number of new lesions over 2-month treatment period · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 2 months Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | MD -3.90 [-4.55, -3.25] | 1 study · 40 participants | Ungraded |
Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs Montelukast (leukotriene receptor antagonist) Total number of new lesions over 2-month treatment period · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 2 months Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | MD -0.30 [-0.90, 0.30] | 1 study · 40 participants | Ungraded |