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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

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Review versions

2 questions in 1 reviews · cluster CL0203

current versions

No studies 0 · 0%Ungraded 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

Question	Effect	Evidence	Status / GRADE
Orthodontic adhesive/composite containing nano-calcium fluoride (n-CaF2), alone or with DMAHDM vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control Enamel remineralization extent · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling 30 days, Overall Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024)	A study using an orthodontic adhesive containing nano-calcium fluoride showed statistically significant remineralization compared with control orthodontic adhesives [35].	1 study	Ungraded
Experimental orthodontic adhesive containing amorphous fluorinated calcium phosphate nanoparticles (n-AFCP) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control Enamel remineralization extent and color change · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling 21 days, Overall Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024)	A study using an orthodontic primer containing amorphous fluorinated calcium phosphate nanoparticles showed statistically significant remineralization and less enamel color change (delta-E) compared with the control…	1 study	Ungraded