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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
15 questions in 2 reviews · cluster CL0197
current versionsNo studies 0 · 0%Ungraded 4 · 26.7%Very low 0 · 0%Low 5 · 33.3%Moderate 6 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hydroxyapatite (e.g., nano-HAp) vs Calcium-based agent Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -1.792 [-7.415, 3.831] | 0 studies | Low |
Hydroxyapatite (e.g., nano-HAp) vs HEMA/EGDMA-based desensitizer Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -4.815 [-10.709, 1.079] | 0 studies | Moderate |
Hydroxyapatite (e.g., nano-HAp) vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -2.916 [-5.854, 0.023] | 5 studies | Moderate |
Hydroxyapatite (e.g., nano-HAp) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.960 [-1.806, 11.727] | 0 studies | Low |
Hydroxyapatite (e.g., nano-HAp) vs Mesoporous silica (SiO2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -3.756 [-10.536, 3.024] | 0 studies | Moderate |
Hydroxyapatite (e.g., nano-HAp) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -4.455 [-8.857, -0.053] | 0 studies | Moderate |
Hydroxyapatite (e.g., nano-HAp) vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.841 [-0.848, 10.530] | 3 studies | Low |
Hydroxyapatite (e.g., nano-HAp) vs Flavonoids (e.g., quercetin, proanthocyanidin) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -7.520 [-14.758, -0.281] | 0 studies | Moderate |
Hydroxyapatite (e.g., nano-HAp) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -2.315 [-6.066, 1.436] | 0 studies | Moderate |
Hydroxyapatite (e.g., nano-HAp) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 3.736 [-3.063, 0.536] | 0 studies | Low |
Hydroxyapatite (e.g., nano-HAp) vs Calcium-based agent Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.333 [-5.240, 13.906] | 0 studies | Low |
Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier Change in probing pocket depth (PPD) · People with at least one dental implant affected by peri-implantitis · 4 years Interventions for replacing missing teeth: treatment of peri‐implantitis (2012) · Cochrane | MD -1.4 [-1.99, -0.81] | 1 study · 22 participants | Ungraded |
Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier Implant failure · People with at least one dental implant affected by peri-implantitis · 6 months Interventions for replacing missing teeth: treatment of peri‐implantitis (2012) · Cochrane | No implant failure occurred in any of the groups. | 1 study · 22 participants | Ungraded |
Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier Change in probing attachment level (PAL) · People with at least one dental implant affected by peri-implantitis · 4 years Interventions for replacing missing teeth: treatment of peri‐implantitis (2012) · Cochrane | MD -1.4 [-2.56, -0.24] | 1 study · 22 participants | Ungraded |
Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier Recurrence of peri-implantitis · People with at least one dental implant affected by peri-implantitis · 4 years Interventions for replacing missing teeth: treatment of peri‐implantitis (2012) · Cochrane | RR 2.0 [0.21, 18.98] | 1 study · 22 participants | Ungraded |