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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

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Review versions

2 questions in 1 reviews · cluster CL0194

current versions

No studies 0 · 0%Ungraded 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

Question	Effect	Evidence	Status / GRADE
CO2 laser combined with fluoride vs Fluoride alone Enamel demineralization / mineral loss · Human enamel specimens under cariogenic challenge (in situ / ex vivo) Clinical and ex-vivo effect of LASERs on prevention of early-enamel caries: systematic review & meta-analyses. (2024)	Narrative only (secondary question: laser-fluoride synergy). Takate: combined low-power CO2 laser plus 1.23% APF gave greater inhibition of mineral loss than either alone (APF after laser gave maximum inhibition).…	2 studies	Ungraded
Low-power CO2 laser irradiation (LLLT, 0.5 to 2 W) vs Placebo / no laser (control) Incidence of new white spot lesions (WSLs) · High caries-risk patients: fixed-orthodontic-appliance patients and children with partially erupted permanent molars · 3 to 18 months follow-up Clinical and ex-vivo effect of LASERs on prevention of early-enamel caries: systematic review & meta-analyses. (2024)	OR 0.21 [0.15, 0.30]	3 studies · 182 participants	Ungraded