Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

3 questions in 3 reviews · cluster CL0167

current versions
No studies 0 · 0%Ungraded 2 · 66.7%Very low 1 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

QuestionEffectEvidenceStatus / GRADE
Microinvasive techniques (resin infiltration, resin/GIC sealant, or glass ionomer varnish) vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)
Adverse events and periodontal/secondary outcomes (gingival bleeding, gingival bleeding index, visible plaque index) · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages… · Baseline and follow-up
Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth-… (2025)
Reported narratively by 3 trials (Arthur 2018, Sarti 2020, Jorge 2019). No adverse events were attributed to microinvasive treatment. Gingival bleeding index: no significant difference in Arthur 2018 and Jorge 2019 but…3 studiesUngraded
Oral health education/promotion (oral hygiene advice plus diet and feeding practice advice) combined with clinical treatment for mother's dentition (basic restorative and preventive; 1 trial included CHX varnish application) vs Standard care
Mother microbiological presence (high-level mutans streptococci / lactobacilli) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6…
Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane
RR 0.53 [0.28, 1.03]1 study · 50 participantsUngraded
Chlorhexidine varnish (10%) vs Placebo or no treatment
Elevated mutans streptococci levels (>=4 with caries screen; high vs low) · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with… · 6 to 36 months, permanent dentition
Chlorhexidine treatment for the prevention of dental caries in children and adolescents (2015) · Cochrane
RR 0.93 [0.80, 1.07]1 study · 496 participantsVery low