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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
6 questions in 5 reviews · cluster CL0131
current versionsNo studies 2 · 33.3%Ungraded 2 · 33.3%Very low 2 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel vs 0 ppm F placebo gel Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond (end of orthodontic treatment) Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | Additional SoF Table 1. Number of participants with more severe DLs: none of the trials reported this outcome. | 0 studies | No studies |
12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel, professionally applied every 3 months plus home use vs 0 ppm F placebo gel Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; mean follow-up 16.6 months Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | RR 0.99 [0.76, 1.27] | 1 study · 312 participants | Very low |
Fluoride gel (450 ppm) vs High-content fluoride toothpaste (1350 ppm) Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the… · 14 to 36 months Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy (2019) · Cochrane | This comparison was only made in 1 study, which showed no difference between the 2 interventions: no patients in either group developed ORN (12- to 36-month follow-up) (0/99 in the fluoride gel group and 0/91 in the… | 1 study · 220 participants | Very low |
1.23% acidulated phosphate fluoride (APF) gel vs Not specified Remineralisation of early enamel caries · Children with incipient (early) enamel caries Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a… (2016) | One double-blind randomised trial found acidulated phosphate fluoride gel was not effective to remineralise early enamel caries. | 1 study | Ungraded |
Glass ionomer sealant (with fluoride gel plus dentifrice) vs Fluoride gel plus fluoride toothpaste/dentifrice (non-invasive control) Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in… · 12 to 36 months (radiographic follow-up), Glass ionomer sealant Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth (2015) · Cochrane | OR 0.13 [0.01, 2.52] | 1 study | Ungraded |
Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs Placebo or no treatment Mucosal irritation / oral soft-tissue allergic reaction · Children and adolescents aged 16 years or younger Fluoride gels for preventing dental caries in children and adolescents (2015) · Cochrane | None of the studies reported this outcome. | 0 studies | No studies |