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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
5 questions in 3 reviews · cluster CL0062
current versionsNo studies 0 · 0%Ungraded 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early childhood caries vs NA (within-white-spot-lesion correlation, not a caries vs caries-free comparison) Correlation of Veillonella spp. with acidogenic streptococci · Young children with early childhood caries and caries-free controls A systematic review of Streptococcus Mutans and Veillonellae species interactions in dental caries… (2025) | R² 0.38 | 1 study · NA (white-spot correlation analytic sample not reported) participants | Ungraded |
Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate) Association between orthodontic treatment duration and ICLs prevalence · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances · During or after fixed orthodontic treatment, By orthodontic treatment duration (subgroup meta-analysis; positive association, P=.01) Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and… (2024) | Prevalence of ICLs positively associated with orthodontic treatment duration (meta-regression, P=.01); effect size/slope not available (Fig. 6a image not provided) | NR | Ungraded |
Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate) Association between patient age and number of ICLs · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances · During or after fixed orthodontic treatment, By patient age (subgroup meta-analysis; no significant association) Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and… (2024) | No significant association found between patient age and the number of ICLs (meta-regression / subgroup analysis) | NR | Ungraded |
Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate) Association between orthodontic treatment duration and ICLs incidence · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new… · During or after fixed orthodontic treatment, By orthodontic treatment duration (subgroup meta-analysis; positive association, P<.01) Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and… (2024) | Incidence of new ICLs positively associated with orthodontic treatment duration (meta-regression, P<.01); effect size/slope not available (Fig. 6b image not provided) | NR | Ungraded |
Dental caries vs Caries-free oral health KEGG pathway associations · Participants in oral 16S rRNA caries microbiome studies Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. (2022) | no estimate extracted | 19 studies · 2016 participants | Ungraded |