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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
371 questions in 6 reviews · cluster CL0008
current versionsNo studies 0 · 0%Ungraded 371 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AMELX rs946252 T allele vs C allele Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls · Ethnicity: Mixed (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.99 [0.53, 1.86] | 1 study | Ungraded |
GG genotype of LTF rs1126478 vs AA + AG genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.92 [0.77, 1.10] | 2 studies | Ungraded |
LTF rs1126478 G allele vs A allele Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.98 [0.87, 1.10] | 4 studies · 2662 participants | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.89 [0.30, 11.85] | 1 study | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 6.17 [0.41, 92.05] | 2 studies | Ungraded |
LTF rs1126477 variant vs Reference allele/genotype Dental caries · Human subjects with dental caries and caries-free controls · Single study (Wang et al. 2018) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.17 [1.06, 1.29] | 1 study · 910 participants | Ungraded |
CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.95 [0.40, 2.25] | 1 study | Ungraded |
AMELX rs17878486 CT + TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Asian (n=1) individuals with caries/high caries and controls · Ethnicity: Asian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.04, 22.53] | 1 study | Ungraded |
AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.16 [0.53, 1.97] | 2 studies | Ungraded |
AMELX rs17878486 T allele vs C allele Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.87 [0.35, 23.23] | 2 studies | Ungraded |
ENAM rs3796703 TT genotype vs CC genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.22 [0.25, 108.96] | 2 studies · 1152 participants | Ungraded |
GG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.30 [0.79, 2.14] | 2 studies | Ungraded |
AMELX rs6639060 T allele vs C allele Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.08 [0.63, 1.85] | 1 study | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.45 [0.92, 2.28] | 2 studies | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.74 [0.27, 2.02] | 3 studies | Ungraded |
rs1126478, additive (per-allele) model vs Reference allele A Dental caries · Human subjects with dental caries and caries-free controls · Sensitivity analysis excluding the study using adult data (Fine 2013) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.47 [0.92, 2.35] | 3 studies · 1752 participants | Ungraded |
CT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.12, 8.23] | 2 studies | Ungraded |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · Severe caries (DMFT 13 to 20); Wang et al. 2018 The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 0.78 [0.70, 0.87] | 1 study | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 3.10 [0.85, 11.28] | 4 studies · 442 participants | Ungraded |
T allele of AMELX rs2106416 vs C allele of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.59 [0.16, 2.11] | 3 studies | Ungraded |
TT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.28, 3.75] | 1 study | Ungraded |
TT genotype of AMELX rs6639060 vs CC + CT genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.42, 2.39] | 2 studies · 301 participants | Ungraded |
rs1126478, allelic model (G allele) vs A allele Dental caries · Human subjects with dental caries and caries-free controls · Allelic model (G vs. A) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.41 [0.48, 4.13] | 4 studies · 1802 participants | Ungraded |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · Moderate caries (DMFT 8 to 12); Wang et al. 2018 The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 0.72 [0.65, 0.80] | 1 study | Ungraded |
TT genotype of AMELX rs946252 vs CC + CT genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.73 [0.19, 2.87] | 2 studies | Ungraded |
CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.45 [0.75, 2.81] | 3 studies · 298 participants | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.65 [0.49, 14.35] | 3 studies | Ungraded |
T allele of AMELX rs946252 vs C allele of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.95 [0.35, 2.55] | 2 studies | Ungraded |
TT genotype of ENAM rs3796703 vs CC + CT genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.90 [0.92, 9.12] | 2 studies | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Adults Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.38 [0.25, 7.75] | 1 study | Ungraded |
CT + TT genotype (T-allele carriers) of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.90 [0.23, 3.63] | 2 studies | Ungraded |
AG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.80, 1.25] | 4 studies | Ungraded |
TT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.22 [0.25, 108.96] | 2 studies | Ungraded |
rs1126478, recessive model (GG genotype) vs GA or AA genotype Dental caries · Human subjects with dental caries and caries-free controls · Recessive model (GG vs. GA + AA) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.55 [0.44, 5.38] | 4 studies · 1802 participants | Ungraded |
CT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 3.42 [1.04, 11.28] | 2 studies | Ungraded |
AMELX rs946252 CT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.80 [0.93, 8.43] | 2 studies | Ungraded |
GG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.80, 1.33] | 4 studies | Ungraded |
ENAM rs3796703 CT + TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls · Ethnicity: Asian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.90 [0.23, 3.63] | 2 studies | Ungraded |
TT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.42 [0.54, 3.76] | 2 studies | Ungraded |
G allele of ENAM rs1264848 vs A allele of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.82 [0.57, 1.18] | 4 studies | Ungraded |
AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.14 [0.01, 1.46] | 1 study | Ungraded |
AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.14 [0.01, 1.46] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Adults Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.04, 22.53] | 1 study | Ungraded |
AG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.57 [0.97, 2.53] | 2 studies | Ungraded |
CT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.27 [0.49, 3.30] | 1 study | Ungraded |
CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.80 [0.93, 8.43] | 2 studies | Ungraded |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · Moderate or severe caries combined; Volckova et al. 2014 The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.88 [1.50, 2.37] | 1 study | Ungraded |
rs1126478, dominant model (GG or GA genotype) vs AA genotype Dental caries · Human subjects with dental caries and caries-free controls · Dominant model (GG + GA vs. AA) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.32 [0.43, 4.03] | 4 studies · 1802 participants | Ungraded |
ENAM rs3796703 T allele vs C allele Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.92 [0.24, 3.58] | 2 studies · 1152 participants | Ungraded |
TT genotype of AMELX rs946252 vs CC + CT genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.04 [0.29, 3.75] | 1 study | Ungraded |