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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
371 questions in 6 reviews · cluster CL0008
current versionsNo studies 0 · 0%Ungraded 371 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
TT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.04 [0.43, 2.51] | 2 studies · 301 participants | Ungraded |
CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.95 [0.40, 2.25] | 1 study | Ungraded |
GG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.62 [0.64, 4.09] | 1 study | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.30 [0.51, 10.33] | 4 studies · 442 participants | Ungraded |
GG genotype of ENAM rs1264848 vs AA + AG genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.09 [0.53, 2.23] | 1 study | Ungraded |
AG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.73 [0.77, 3.90] | 1 study | Ungraded |
GG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.61 [0.13, 2.93] | 2 studies | Ungraded |
AMELX rs17878486 T allele vs C allele Dental caries susceptibility · Ethnicity: Asian (n=1) individuals with caries/high caries and controls · Ethnicity: Asian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.38 [0.25, 7.75] | 1 study | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Adults Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.89 [0.30, 11.85] | 1 study | Ungraded |
AMELX rs2106416 CT genotype vs CC genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=3) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.55 [0.13, 2.25] | 3 studies · 285 participants | Ungraded |
LTF rs1126478 GG genotype vs AA + AG genotype Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls · Age group: Children (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.95 [0.80, 1.13] | 4 studies | Ungraded |
Multiple LTF gene variants (joint / gene-based) vs Caries-free controls Dental caries · Human subjects with dental caries and caries-free controls · Gene-based joint association (LTF) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | P-value (gene-based, weighted TPM) 0.0007 | NR | Ungraded |
GG genotype of ENAM rs3796704 vs AA + AG genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.43 [0.67, 3.05] | 1 study | Ungraded |
AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.02 [0.78, 1.33] | 2 studies | Ungraded |
TT genotype of AMELX rs2106416 vs CC + CT genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.67 [0.44, 6.34] | 2 studies | Ungraded |
AMELX rs17878486 CT + TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.03 [0.10, 42.44] | 2 studies | Ungraded |
AMELX rs6639060 CT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.27 [0.49, 3.30] | 1 study | Ungraded |
ENAM rs3796703 CT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls · Ethnicity: Asian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.23, 3.48] | 2 studies | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.69 [0.78, 3.68] | 1 study | Ungraded |
CT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.72 [0.37, 7.92] | 3 studies | Ungraded |
rs1126478, co-dominant model (GA genotype) vs GG or AA genotype Dental caries · Human subjects with dental caries and caries-free controls · Co-dominant model (GA vs. GG + AA) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 0.97 [0.72, 1.32] | 4 studies · 1802 participants | Ungraded |
TT genotype of AMELX rs946252 vs CC + CT genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.73 [0.19, 2.87] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 3.43 [1.21, 9.75] | 2 studies | Ungraded |
G allele of LTF rs1126478 vs A allele of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.98 [0.87, 1.10] | 4 studies | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.64 [0.86, 3.14] | 4 studies · 1107 participants | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.82 [1.06, 3.11] | 2 studies | Ungraded |
T allele of AMELX rs6639060 vs C allele of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.08 [0.63, 1.85] | 1 study | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 3.55 [0.72, 17.60] | 3 studies | Ungraded |
LTF rs1126478 AG + GG genotype vs AA genotype Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls · Age group: Children (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.99 [0.81, 1.23] | 4 studies | Ungraded |
T allele of AMELX rs6639060 vs C allele of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Adults Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.08 [0.63, 1.85] | 1 study | Ungraded |
G allele of ENAM rs1264848 vs A allele of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.83, 1.29] | 2 studies | Ungraded |
ENAM rs3796703 T allele vs C allele Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls · Ethnicity: Asian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.92 [0.24, 3.58] | 2 studies | Ungraded |
TT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.83 [0.47, 7.06] | 3 studies · 285 participants | Ungraded |
TT genotype of ENAM rs3796703 vs CC + CT genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.90 [0.92, 9.12] | 2 studies · 1152 participants | Ungraded |
ENAM rs3796703 CT + TT genotype vs CC genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.90 [0.23, 3.63] | 2 studies · 1152 participants | Ungraded |
AMELX rs2106416 T allele vs C allele Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=3) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.59 [0.16, 2.11] | 3 studies · 285 participants | Ungraded |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · Moderate caries (DMFT 2 to 3); Volckova et al. 2014 The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.04 [0.80, 1.34] | 1 study | Ungraded |
T allele of AMELX rs2106416 vs C allele of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.59 [0.16, 2.11] | 3 studies · 285 participants | Ungraded |
T allele of AMELX rs946252 vs C allele of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.99 [0.53, 1.86] | 1 study | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.44 [0.75, 2.77] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.04, 22.53] | 1 study | Ungraded |
CT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.23, 3.48] | 2 studies | Ungraded |
GG genotype of LTF rs1126478 vs AA + AG genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.33 [0.77, 2.29] | 2 studies | Ungraded |
T allele of AMELX rs946252 vs C allele of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.21 [0.77, 1.91] | 2 studies | Ungraded |
G allele of ENAM rs3796704 vs A allele of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.43 [1.10, 1.85] | 3 studies | Ungraded |
TT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 4.69 [0.55, 40.16] | 3 studies | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.16 [0.76, 1.75] | 4 studies | Ungraded |
GG genotype of ENAM rs1264848 vs AA + AG genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.83 [0.44, 1.58] | 5 studies · 1534 participants | Ungraded |
TT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.22 [0.25, 108.96] | 2 studies | Ungraded |
LTF rs1126478 GG genotype vs AA genotype Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls · Age group: Children (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.80, 1.33] | 4 studies | Ungraded |