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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

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Review versions

1 questions in 1 reviews · intervention: Probiotics · outcome domain: White-spot/initial lesions

current versions

No studies 0 · 0%Ungraded 1 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

Question	Effect	Evidence	Status / GRADE
Postbiotics from Lactobacillus spp. (cell-free supernatants, biosurfactants, lipoteichoic acid, bacterial lysates) vs Untreated control Reduced enamel demineralization · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro · Exposure 24 h to 7 days Postbiotics and Dental Caries: A Systematic Review. (2025)	One in vitro multispecies-biofilm study reported that a postbiotic (L. reuteri cell-free supernatant) reduced enamel demineralization, indicating a protective effect against caries; no pooled estimate.	1 study	Ungraded