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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
8 questions in 1 reviews · intervention: Pit-and-fissure sealants · outcome domain: White-spot/initial lesions
current versionsNo studies 0 · 0%Ungraded 5 · 62.5%Very low 3 · 37.5%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sealant/coating agent WITH fluoride release applied to teeth with fixed appliances vs No sealant (untreated control teeth) Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances · 3-27 months follow-up, Sealant with fluoride release Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel… (2021) | RR 0.69 [0.46, 1.05] | 3 studies · 1467 participants | Ungraded |
Sealant vs No sealant Incidence of new white spot lesions by visual-tactile assessment · Patients receiving comprehensive fixed orthodontic treatment · 3 to 27 months, Overall Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel… (2021) | RR 0.70 [0.53, 0.93] | 6 studies · 2314 participants | Very low |
Sealant/coating agent WITHOUT fluoride release applied to teeth with fixed appliances vs No sealant (untreated control teeth) Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances · 3-27 months follow-up, Sealant without fluoride release Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel… (2021) | RR 0.69 [0.49, 0.97] | 3 studies · 847 participants | Ungraded |
Sealant or coating agent (with or without fluoride release) applied to teeth with fixed appliances vs No sealant (untreated control teeth) White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel… (2021) | Laser fluorescence (DIAGNOdent) was assessed in 3 studies comparing sealant vs no sealant, but meta-analysis could not be performed because results were presented parametrically or non-parametrically without the… | 3 studies | Ungraded |
Fluoride-releasing resin-based sealant vs Non-fluoride resin-based sealant Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances · 1-24 months follow-up, Resin-based sealants Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel… (2021) | RR 0.71 [0.35, 1.43] | 2 studies · 644 participants | Ungraded |
Sealant or coating agent (with or without fluoride release) applied to teeth with fixed appliances vs No sealant (untreated control teeth) Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances · 3-27 months follow-up Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel… (2021) | RR 0.70 [0.53, 0.93] | 6 studies · 2314 participants | Very low |
Coating material (bonding material or sealant) WITH fluoride release vs Coating material WITHOUT fluoride release White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel… (2021) | Laser fluorescence (DIAGNOdent) was assessed in 3 studies comparing coating with vs without fluoride release, but meta-analysis could not be performed (results reported using incompatible continuous/categorical formats… | 3 studies | Ungraded |
Coating material (bonding material or sealant) WITH fluoride release vs Coating material WITHOUT fluoride release Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances · 1-24 months follow-up Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel… (2021) | RR 0.84 [0.70, 1.01] | 10 studies · 4705 participants | Very low |