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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Review versions

8 questions in 2 reviews · intervention: Pit-and-fissure sealants · outcome domain: Caries incidence/onset

current versions

No studies 0 · 0%Ungraded 1 · 12.5%Very low 2 · 25%Low 5 · 62.5%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

Question	Effect	Evidence	Status / GRADE
Fluoride-releasing resin-based sealant vs No sealant (no treatment) Development of >=1 new carious lesion (caries incidence) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department,… · 12 months Sealants for preventing dental caries in primary teeth (2022) · Cochrane	BB OR 1.21 [0.37, 3.94]	1 study · 88 participants	Low
Glass ionomer-based sealant vs No sealant Development of >=1 new carious lesion (caries incidence) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric… · 6-12 months Sealants for preventing dental caries in primary teeth (2022) · Cochrane	OR 0.033 [0.007, 0.149]	1 study · 107 participants	Low
Glass ionomer-based sealant vs No sealant Development of >=1 new carious lesion (caries incidence) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric… · 12-30 months Sealants for preventing dental caries in primary teeth (2022) · Cochrane	OR 0.97 [0.63, 1.49]	1 study · 449 participants	Low
Glass ionomer-based sealant vs Resin-based sealant (fluoride-releasing or non-fluoride-releasing) Development of >=1 new carious lesion (caries incidence) · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China) · 6-24 months Sealants for preventing dental caries in primary teeth (2022) · Cochrane	N/A - insufficient quantitative information available; 200 (2 studies). Comments: Due to the methods of data collection, analysis and reporting we were unable to provide any quantitative estimates. Fei 2011 narrative:…	2 studies · 200 participants	Very low
Fluoride-releasing resin-based sealant vs Resin-based sealant Development of >=1 new carious lesion (caries incidence) · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain) · 6-24 months Sealants for preventing dental caries in primary teeth (2022) · Cochrane	N/A - insufficient quantitative information available; 69 (2 studies). Comments: Due to the different sealant materials, data reporting (split-mouth studies reported as parallel-group) and the very low number of tooth…	2 studies · 69 participants	Low
Autopolymerised sealant vs Light polymerised sealant Development of >=1 new carious lesion (caries incidence) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark) · 24-36 months Sealants for preventing dental caries in primary teeth (2022) · Cochrane	OR 0.58 [0.15, 2.19]	1 study · 52 participants	Very low
Fluoride-releasing resin-based sealant vs No sealant (no treatment) Development of >=1 new carious lesion (caries incidence) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department,… · 24 months Sealants for preventing dental caries in primary teeth (2022) · Cochrane	BB OR 0.76 [0.41, 1.42]	1 study · 85 participants	Low
Resin-based pit and fissure sealant (PFS) vs Fluoride varnish (FV) Caries incidence in first permanent molars · Schoolchildren aged 6-12 years with sound occlusal surfaces of the first permanent molars · 24 months Pit and Fissure Sealant versus Fluoride Varnish for the Prevention of Dental Caries in School Children: A… (2022)	RR 0.65 [0.31, 1.38]	3 studies · 1263 participants	Ungraded