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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
12 questions in 6 reviews · intervention: Pit-and-fissure sealants · outcome domain: Adverse effects/fluorosis
current versionsNo studies 7 · 58.3%Ungraded 4 · 33.3%Very low 1 · 8.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
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| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride-releasing resin-based sealant vs Resin-based sealant Adverse events · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain) Sealants for preventing dental caries in primary teeth (2022) · Cochrane | No studies reported this outcome. | 0 studies | No studies |
Glass ionomer-based sealant vs No sealant Adverse events · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric… Sealants for preventing dental caries in primary teeth (2022) · Cochrane | No studies reported this outcome. | 0 studies | No studies |
Autopolymerised sealant vs Light polymerised sealant Adverse events · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark) Sealants for preventing dental caries in primary teeth (2022) · Cochrane | No studies reported this outcome. | 0 studies | No studies |
Fluoride-releasing resin-based sealant vs No sealant (no treatment) Adverse events · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department,… Sealants for preventing dental caries in primary teeth (2022) · Cochrane | No studies reported this outcome. | 0 studies | No studies |
Glass ionomer-based sealant vs Resin-based sealant (fluoride-releasing or non-fluoride-releasing) Adverse events · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China) Sealants for preventing dental caries in primary teeth (2022) · Cochrane | 1 study reported adverse events as some discomfort such as nausea; 1 child experienced a strong gag reflex following the glass ionomer-based sealant while 8 children reported feeling uncomfortable after the fluoride… | 1 study · 100 participants | Very low |
Any of the interventions (CR, SE, SW, sealing with sealant materials, Hall Technique, or NRCC) vs Each other, placebo, or no treatment Safety issues (adverse events) · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… Interventions for treating cavitated or dentine carious lesions (2021) · Cochrane | None of the studies reported adverse effects. | 0 studies | No studies |
Resin-based fissure sealant vs Fluoride varnish Safety of sealants and fluoride varnishes (adverse events) · Children and adolescents from the general population, younger than 20 years of age at the start of the study Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of… (2020) · Cochrane | Five studies (Bravo 2005; Chestnutt 2017; Kalnina 2016; Liu 2012; Tagliaferro 2011) considered adverse events; participants detected and reported no adverse events. | 5 studies | Ungraded |
Horizontal mattress / fibrin sealant suturing vs Conventional (simple interrupted) suturing Adverse effects · Adults with mandibular third molars requiring removal · up to 30 days Surgical techniques for the removal of mandibular wisdom teeth (2020) · Cochrane | no estimate extracted | NR | No studies |
Resin-based fissure sealant (2nd/3rd/4th generation) vs No sealant (control/no treatment) Adverse effects · Children and adolescents (general population, aged under 20 years) Pit and fissure sealants for preventing dental decay in permanent teeth (2017) · Cochrane | Two trials measured adverse effects. None were reported. | 2 studies | Ungraded |
Glass ionomer-based sealant vs No sealant (control/no treatment) Adverse effects · Children and adolescents (general population, aged under 20 years) Pit and fissure sealants for preventing dental decay in permanent teeth (2017) · Cochrane | Adverse effects not measured. | NR | No studies |
Glass ionomer-based sealant vs Resin-based sealant Adverse effects · Children and adolescents (general population, aged under 20 years) Pit and fissure sealants for preventing dental decay in permanent teeth (2017) · Cochrane | One trial measured adverse effects. None reported. | 1 study | Ungraded |
Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive measures (e.g. fluoride varnish, flossing/oral hygiene advice), no treatment, or placebo Adverse events · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in… · 1 to 3 years Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth (2015) · Cochrane | The four studies that measured adverse events reported no adverse events after micro-invasive treatment (no events in either arm) | 4 studies | Ungraded |