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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
7 questions in 1 reviews · intervention: Herbal/natural product · outcome domain: Microbiological/plaque
current versionsNo studies 0 · 0%Ungraded 7 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Grape seed extract or grape seed flavonoid fractions vs No extract or vehicle control; other antimicrobial agents Biofilm morphology · Streptococcus mutans cultures and biofilms Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | no estimate extracted | 2 studies | Ungraded |
Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | Cranberry extract/PAC reduced S. mutans biofilm formation: 51% at 500 ug/mL (Philip 2019), 95.2% at 50 mg/mL (Sumathi), 50-70% of preformed biofilm at 16.67-20.83 mg/dL (Singhal), 32%/29%/14% at 500/250/125 ug/mL… | 10 studies | Ungraded |
Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | Cranberry treatment disrupted biofilm integrity with agglutination/cell degradation at higher concentrations (Singhal), reduced polymicrobial biomass 38% at 96 h (Philip 2019), produced defective accumulation and… | 4 studies | Ungraded |
Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | GSE decreased microcolony number and biofilm thickness at 2000 ug/mL (Furiga) and significantly altered bacterial cell structure with 50 ug/2 mL GSE candy (Nowaczyk). | 2 studies | Ungraded |
Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | GSE reduced biofilm formation: 89% (polymeric PAC) vs 79% (dealcoholized wine) (Daglia), inhibition at 4 mg/mL (Zhao), decreased microcolonies with 2000 ug/mL GSE + fluorinol (Furiga), reduction within 30 min… | 5 studies | Ungraded |
Cranberry extract or cranberry flavonoid fractions vs No extract or vehicle control; other antimicrobial agents Biofilm formation · Streptococcus mutans cultures and biofilms Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | no estimate extracted | 10 studies | Ungraded |
Cranberry extract or cranberry flavonoid fractions vs No extract or vehicle control; other antimicrobial agents Biofilm morphology or biomass · Streptococcus mutans cultures and biofilms Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | no estimate extracted | 4 studies | Ungraded |