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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2 questions in 1 reviews · intervention: Fluoride varnish · outcome domain: White-spot/initial lesions
current versionsNo studies 0 · 0%Ungraded 1 · 50%Very low 1 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride varnish applied periodically (at least quarterly) around the bracket bases during treatment vs Placebo varnish, resin sealant, or standard care (oral hygiene instructions) Prevalence of white spot lesions (WSL) at debonding, subject level · Healthy adolescents and adults undergoing orthodontic treatment with fixed multi-bracket appliances · At debonding Prevention of white spot lesions with fluoride varnish during orthodontic treatment with fixed appliances: a… (2023) | RR 0.64 [0.42, 0.98] | 5 studies · 558 participants | Very low |
Fluoride varnish applied periodically (at least quarterly) around the bracket bases during treatment vs Placebo varnish, resin sealant, or standard care (oral hygiene instructions) White spot lesion clinical score (mean values), subject level · Healthy adolescents and adults undergoing orthodontic treatment with fixed multi-bracket appliances · At debonding Prevention of white spot lesions with fluoride varnish during orthodontic treatment with fixed appliances: a… (2023) | SMD -0.44 [-0.64, -0.24] | 2 studies · 258 participants | Ungraded |