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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
10 questions in 4 reviews · intervention: Fluoride varnish · outcome domain: Caries incidence/onset
current versionsNo studies 0 · 0%Ungraded 10 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride varnish applied biannually vs Fissure sealant (resin-based or glass ionomer) Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures… · 2 to 3 years, Sensitivity analysis excluding Bravo 1996 (high risk of bias) Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a… (2020) | RR 1.05 [0.91, 1.22] | 5 studies | Ungraded |
Fluoride varnish applied biannually vs Fissure sealant (resin-based or glass ionomer) Caries incidence (proportion of enrolled children developing dentin caries, ICDAS 4-6) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures… · 2 to 3 years Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a… (2020) | RR 1.12 [0.60, 2.09] | 2 studies · 1072 participants | Ungraded |
Fluoride varnish applied biannually vs Fissure sealant (resin-based or glass ionomer) Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures… · 2 to 3 years Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a… (2020) | RR 1.29 [0.95, 1.75] | 6 studies · 6878 participants | Ungraded |
Fluoride varnish applied biannually vs Fissure sealant (resin-based or glass ionomer) Caries incidence of occlusal surfaces of first permanent molars · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures… · 2 to 3 years, Sensitivity analysis excluding Bravo 1996 (high risk of bias) Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a… (2020) | RR 0.98 [0.82, 1.16] | 3 studies | Ungraded |
Fluoride varnish applied biannually vs Fissure sealant (resin-based or glass ionomer) Caries incidence of occlusal surfaces of first permanent molars · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures… · 2 to 3 years Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a… (2020) | RR 1.33 [0.83, 2.11] | 4 studies · 6551 participants | Ungraded |
Fluoride varnish applied biannually vs Fissure sealant (resin-based or glass ionomer) Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures… · 2 to 3 years, Sensitivity analysis excluding split-mouth design (Raadal 1984) Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a… (2020) | RR 1.29 [0.88, 1.87] | 5 studies | Ungraded |
Fluoride varnish vs Placebo or no treatment Proportion of children developing one or more new caries (primary/deciduous dentition, d(e/m)ft) · Children and adolescents aged 16 years or less · At least 1 year, Primary/deciduous dentition Fluoride varnishes for preventing dental caries in children and adolescents (2013) · Cochrane | RR 0.81 [0.62, 1.06] | 5 studies · 1228 participants | Ungraded |
Fluoride varnish vs Placebo or no treatment Proportion of children developing one or more new caries (permanent dentition, D(M)FT) · Children and adolescents aged 16 years or less · At least 1 year Fluoride varnishes for preventing dental caries in children and adolescents (2013) · Cochrane | RR 0.75 [0.53, 1.05] | 5 studies · 3253 participants | Ungraded |
Fluoride varnish vs Fluoride toothpaste Proportion of children developing new caries (deciduous) · Children or adolescents aged 16 or less at the start of the study One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing… (2004) · Cochrane | Petersson 1985 reported the proportion of children developing one or more new carious deciduous surfaces; exactly the same proportions were reported in both groups (no evidence of a difference). | 1 study | Ungraded |
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs Placebo or no treatment Proportion of children developing one or more new caries · Children and adolescents aged 16 years or younger (permanent dentition) Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and… (2003) · Cochrane | RR 0.88 [0.82, 0.95] | 13 studies | Ungraded |