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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2 questions in 2 reviews · intervention: Fluoride toothpaste/dentifrice · outcome domain: White-spot/initial lesions
current versionsNo studies 0 · 0%Ungraded 1 · 50%Very low 1 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Control: fluoride toothpaste alone, placebo mouthrinse + toothpaste, or non-fluoride (chlorhexidine) mouthrinse + toothpaste Incidence of initial enamel caries / white spot lesions adjacent to bracket base (subject level, dichotomized) · Children, adolescents and adults undergoing fixed (multi-bracket) orthodontic treatment · End of intervention (6-26 months) to within 6 weeks after debonding Fluoride mouthrinses for prevention of initial caries in orthodontic patients - a systematic review and… (2025) | RD -0.07 [-0.14, -0.01] | 5 studies · 491 participants | Ungraded |
1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily White spot lesion index (mean change from baseline) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 1.5 years Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | MD -0.05 [-0.10, 0] | 1 study · 97 participants | Very low |