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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
78 questions in 8 reviews · intervention: Fluoride toothpaste/dentifrice · outcome domain: Caries increment (DMFS/DMFT)
current versionsNo studies 0 · 0%Ungraded 25 · 32.1%Very low 3 · 3.8%Low 37 · 47.4%Moderate 9 · 11.5%High 4 · 5.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
440 to 550 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.18 [-0.41, 0.04] | 2 studies | Low |
1000 to 1250 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.14 [-0.24, -0.04] | 7 studies | Low |
1450 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, tooth index d(m)ft · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · Follow-up: 22 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | MD -0.4 [-1.14, 0.34] | 1 study · 172 participants | Low |
1000 to 1250 ppm F toothpaste vs 440 to 550 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.08 [-0.3, 0.15] | 1 study | Low |
1450 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, surface index d(m)fs · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · Follow-up: 22 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | MD -1.2 [-2.92, 0.52] | 1 study · 172 participants | Low |
1000 or 1100 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, tooth index DMFT · Adults with mature permanent dentition (aged 18 to 93 years at study start) · 24 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | MD -0.46 [-0.93, 0.01] | 1 study · 247 participants | Low |
2400 to 2800 ppm F toothpaste vs 1700 to 2200 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.05 [-0.27, 0.17] | NR | Very low |
1700 to 2200 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.07 [-0.3, 0.15] | 1 study | Very low |
2400 to 2800 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.12 [-0.2, -0.05] | 6 studies | Low |
1450 to 1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.39 [-0.49, -0.28] | 4 studies | Moderate |
Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in the United Kingdom · Country: United Kingdom Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among… (2019) | OR 0.04 [0.00, 0.58] | 5 studies | Ungraded |
2400 to 2800 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.39 [-0.52, -0.25] | 2 studies | Low |
1450 to 1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.36 [-0.43, -0.29] | 4 studies | Moderate |
1700 to 2200 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.33 [-0.56, -0.11] | NR | Low |
250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.15 [-0.25, -0.05] | 3 studies | Low |
1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.13 [-0.23, -0.02] | 4 studies | Low |
1450 to 1500 ppm F toothpaste vs 440 to 550 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.2 [-0.45, 0.04] | NR | Low |
2400 to 2800 ppm F toothpaste vs 1700 to 2200 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.09 [-0.2, 0.02] | 1 study | Low |
1700 to 2200 ppm F toothpaste vs 1450 to 1500 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD 0.04 [-0.07, 0.15] | NR | Moderate |
2400 to 2800 ppm F toothpaste vs 1450 to 1500 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD 0.0 [-0.16, 0.17] | NR | Low |
2400 to 2800 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.28 [-0.48, -0.08] | NR | Low |
Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in Ireland · Country: Ireland Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among… (2019) | OR 0.52 [0.45, 0.61] | 1 study | Ungraded |
1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste Caries increment, tooth index d(m)ft · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · Follow-up: 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | MD -0.27 [-0.6, 0.06] | 1 study · 905 participants | Low |
Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in Japan · Country: Japan Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among… (2019) | OR 0.00 [0.00, 0.00] | 1 study | Ungraded |
1000 to 1250 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.15 [-0.31, 0.0] | 3 studies | Low |
1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste Caries increment, surface index d(m)fs · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · Follow-up: 20 to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | MD -0.05 [-0.38, 0.28] | 2 studies · 1958 participants | Moderate |
1700 to 2200 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.32 [-0.41, -0.22] | NR | Low |
1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, surface index d(m)fs · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · Follow-up: 24 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | MD -1.86 [-2.51, -1.21] | 1 study · 998 participants | Moderate |
2400 to 2800 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.26 [-0.38, -0.14] | NR | Low |
Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions Incremental cost-effectiveness per DMFT/S · Children younger than 6 years (healthy except for dental caries) · Age < 6 years Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among… (2019) | OR 0.07 [0.02, 0.32] | 6 studies | Ungraded |
Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published 2015 or later) · Published 2015 or later Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among… (2019) | OR 0.08 [0.01, 0.53] | 4 studies | Ungraded |
440 to 550 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.08 [-0.32, 0.17] | 1 study | Low |
1700 to 2200 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.17 [-0.3, -0.04] | NR | Low |
1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.26 [-0.31, -0.21] | 41 studies | High |
2400 to 2800 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.12 [-0.25, 0.01] | 3 studies | Very low |
2400 to 2800 ppm F toothpaste vs 440 to 550 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.29 [-0.49, -0.08] | NR | Low |
1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.08 [-0.14, -0.01] | 10 studies | Moderate |
1700 to 2200 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.23 [-0.5, 0.05] | NR | Low |
2400 to 2800 ppm F toothpaste vs 440 to 550 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.2 [-0.46, 0.05] | NR | Low |
440 to 550 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.12 [-0.31, 0.07] | 2 studies | Low |
1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, tooth index d(m)ft · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 12 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | No studies reported poolable d(m)ft increment; Cahen 1982 reported a df-rate of 18.25% (n=708) in the 0 ppm group vs 13.64% (n=632, 1500 ppm SMFP) and 9.37% (n=668, amine fluoride) groups. | 1 study | Ungraded |
1450 to 1500 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.28 [-0.47, -0.09] | NR | Low |
Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (healthy except for dental caries) Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among… (2019) | OR 0.19 [0.10, 0.39] | 8 studies | Ungraded |
1700 to 2200 ppm F toothpaste vs 1450 to 1500 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD 0.05 [-0.19, 0.3] | NR | Low |
1450 to 1500 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.21 [-0.33, -0.1] | NR | Low |
Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in Finland · Country: Finland Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among… (2019) | OR 0.48 [0.41, 0.56] | 1 study | Ungraded |
1000 to 1250 ppm F toothpaste vs 440 to 550 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.16 [-0.35, 0.03] | 1 study | Low |
Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published before 2015) · Published before 2015 Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among… (2019) | OR 0.01 [0.00, 0.13] | 4 studies | Ungraded |
1000 or 1100 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, surface index DMFS · Adults with mature permanent dentition (aged 18 to 93 years at study start) · 12 to 24 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | MD -0.53 [-1.02, -0.04] | 3 studies · 2162 participants | Moderate |
1450 to 1500 ppm F toothpaste vs 440 to 550 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.24 [-0.44, -0.04] | NR | Low |