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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

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Review versions

10 questions in 3 reviews · intervention: Fluoride toothpaste/dentifrice · outcome domain: Caries incidence/onset

current versions

No studies 1 · 10%Ungraded 2 · 20%Very low 0 · 0%Low 6 · 60%Moderate 1 · 10%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

Question	Effect	Evidence	Status / GRADE
1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.86 [0.74, 0.99]	1 study · 905 participants	Low
1450 ppm F toothpaste vs 440 ppm F toothpaste Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 60 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.87 [0.81, 0.94]	1 study · 2362 participants	Moderate
1000 or 1100 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Adults with mature permanent dentition (aged 18 to 93 years at study start) Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	Proportion of adults developing new caries: no studies reported this outcome.	0 studies	No studies
1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 12 to 60 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.9 [0.77, 1.06]	7 studies · 1898 participants	Low
1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 1.02 [0.93, 1.11]	2 studies · 4328 participants	Low
1450 to 1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.95 [0.91, 0.98]	1 study · 945 participants	Low
1450 ppm F toothpaste vs 250 ppm F toothpaste Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 22 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.92 [0.54, 1.57]	1 study · 172 participants	Low
250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 24 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 1.07 [0.91, 1.27]	2 studies · 684 participants	Low
Fluoride toothpaste vs Fluoride mouthrinse Proportion of children developing new caries (permanent) · Children or adolescents aged 16 or less at the start of the study One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing… (2004) · Cochrane	RR 0.90 [0.60, 1.37]	1 study	Ungraded
Fluoride toothpaste vs Placebo (non-fluoride) toothpaste Proportion of children developing one or more new caries · Children and adolescents aged 16 years or less · At least 1 year Fluoride toothpastes for preventing dental caries in children and adolescents (2003) · Cochrane	RR 0.91 [0.80, 1.04]	7 studies · 2878 participants	Ungraded