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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
5 questions in 2 reviews · intervention: Fluoride supplements · outcome domain: Adverse effects/fluorosis
current versionsNo studies 1 · 20%Ungraded 1 · 20%Very low 3 · 60%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Placebo or no treatment Adverse effects (apart from fluorosis) · Pregnant women (for preventing dental caries in the primary teeth of their children) Fluoride supplementation (with tablets, drops, lozenges or chewing gum) in pregnant women for preventing… (2017) · Cochrane | no estimate extracted | 1 study | Ungraded |
Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Placebo or no treatment Fluorosis (maxillary teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children) · 5 years Fluoride supplementation (with tablets, drops, lozenges or chewing gum) in pregnant women for preventing… (2017) · Cochrane | RR 1.79 [0.95, 3.40] | 1 study · 798 participants | Very low |
Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Placebo or no treatment Fluorosis (mandibular teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children) · 5 years Fluoride supplementation (with tablets, drops, lozenges or chewing gum) in pregnant women for preventing… (2017) · Cochrane | RR 0.89 [0.35, 2.29] | 1 study · 798 participants | Very low |
Fluoride supplements (tablets, drops, lozenges or chewing gums) vs Topical fluoride (fluoride rinse, varnish or toothpaste) Fluorosis (adverse effect; % of children with fluorotic teeth) · Children and adolescents (aged 16 years or less at baseline) Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children (2011) · Cochrane | Summary of findings 2 lists fluorosis (% of children with fluorotic teeth) as 'See comment / Not estimable / Not estimated'; no included study reported fluorosis for the fluoride supplements versus topical fluoride… | NR | No studies |
Fluoride supplements (tablets, drops, lozenges or chewing gums) vs No fluoride supplement (placebo or no treatment) Fluorosis (adverse effect; % of children with fluorotic teeth, questionable to severe) · Children and adolescents (aged 16 years or less at baseline) · 55 months Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children (2011) · Cochrane | % of children with fluorotic teeth (questionable to severe), follow-up 55 months. Assumed risk 32/212 = 15%; corresponding risk 40/202 = 20% (APF once a day) and 43/197 = 22% (APF twice a day). Relative effect: Not… | 1 study · 611 participants | Very low |