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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
4 questions in 3 reviews · intervention: Fluoride gel/foam · outcome domain: Adverse effects/fluorosis
current versionsNo studies 1 · 25%Ungraded 0 · 0%Very low 3 · 75%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride gel (450 ppm) vs High-content fluoride toothpaste (1350 ppm) Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the… · 14 to 36 months Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy (2019) · Cochrane | Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events | 1 study · 220 participants | Very low |
12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel vs 0 ppm F placebo gel Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; mean follow-up 16.6 months Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | Additional SoF Table 1. Adverse effects: with placebo gel 0.60%; with fluoride gel 0.00% (0 to 0); difference 0.60% fewer (0.60 fewer to 0.60 fewer); relative effect not estimable; 312 participants (1 RCT); certainty… | 1 study · 312 participants | Very low |
Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs Placebo or no treatment Tooth staining · Children and adolescents aged 16 years or younger Fluoride gels for preventing dental caries in children and adolescents (2015) · Cochrane | None of the studies reported on staining of tooth surfaces (not even Gisselsson 1999, the only trial testing stannous fluoride). | 0 studies | No studies |
Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs Placebo or no treatment Signs of acute toxicity during gel application (nausea, gagging, vomiting) · Children and adolescents aged 16 years or younger · During gel application Fluoride gels for preventing dental caries in children and adolescents (2015) · Cochrane | RD 0.01 [-0.01, 0.02] | 2 studies · 490 participants | Very low |