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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
5 questions in 2 reviews · intervention: Exposure: microbial · outcome domain: Diagnostic accuracy
current versionsNo studies 4 · 80%Ungraded 1 · 20%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome Discrimination of caries vs health (random forest ROC-AUC) · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies… Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. (2022) | AUC 0.75 | 19 studies · 2016 participants | Ungraded |
COE with blood/salivary (biomarker) analysis vs Reference standard: examination and clinical evaluation by a physician/clinician with specialist knowledge or training (long-term follow-up accepted for those screened negative) Outcome NR · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance… Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in… (2021) · Cochrane | There were no eligible studies evaluating blood or salivary sample analysis (which tests for the presence of biomarkers for OPMD and OSCC). | 0 studies | No studies |
COE with blood/salivary (biomarker) analysis vs COE with vital rinsing (toluidine blue/tolonium chloride) Outcome NR · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance… Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in… (2021) · Cochrane | No eligible studies; planned comparative analysis (COE with vital rinse vs COE with blood/salivary analysis) not populated in this version. | 0 studies | No studies |
COE with blood/salivary (biomarker) analysis vs Conventional oral examination (COE) alone Outcome NR · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance… Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in… (2021) · Cochrane | No eligible studies; planned comparative analysis (COE vs COE with blood/salivary analysis) not populated in this version. | 0 studies | No studies |
COE with blood/salivary (biomarker) analysis vs COE with light-based detection (e.g. ViziLite Plus, Microlux/DL, VELscope, Identafi 3000) Outcome NR · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance… Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in… (2021) · Cochrane | No eligible studies; planned comparative analysis (COE with light-based detection vs COE with blood/salivary analysis) not populated in this version. | 0 studies | No studies |