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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Review versions

2 questions in 1 reviews · intervention: Exposure: genetic · outcome domain: Periodontal/gingival

current versions

No studies 0 · 0%Ungraded 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

Question	Effect	Evidence	Status / GRADE
Genome-wide common variants (additive dosage; present-study GWAS) vs Genome-wide significance threshold (P<5E-8) Periodontal disease - genome-wide-significant loci (present study) · Japanese adults (present-study cohort: 7,059 periodontal disease cases / 38,466 controls) · Lifelong (germline genotype), Present-study GWAS (Japanese) Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024)	In the present Japanese GWAS, no loci reached genome-wide significance for periodontal disease; several loci reached the suggestive level (P<1E-5). Top-associated variant rs12624579 (SYNDIG1 intron).	1 study · 45525 participants	Ungraded
Genome-wide common variants (additive dosage; GWAS meta-analysis) vs Genome-wide significance threshold (P<5E-8) Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB + BBJ Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024)	Meta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present…	4 studies · 764572 participants	Ungraded